Coverage Geometry and Heuristic Discovery Times in Protein Sequence Space
The paper introduces a geometric framework to analyze protein sequence space coverage and connects it to heuristic discovery times using a stochastic exploration model.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
The paper introduces a geometric framework to analyze protein sequence space coverage and connects it to heuristic discovery times using a stochastic exploration model.
Ekaterina Noskova, Madleina Caduff, Andreas Füglistaler…·Daniel Wegmann
SweepLink jointly infers demography and linked selection from time-series data, improving detection of selection signals compared to single-locus methods.
X. Ramos, Katie Reding, Leslie Pick
This study investigates PR-gene expression and function in Vanessa cardui, finding that lepidopterans use a subset of Drosophila PR-gene orthologs and lack hemipteran PR-orthologs for segmentation.
Luise Häuser, Alexandros Stamatakis
The paper evaluates 54 tree shape indices on 45 million empirical trees, revealing rooting and size dependencies, and recommends selecting uncorrelated indices for reliable tree shape analysis.
Malahat Dianat, Violaine Nicolas, Inessa Voet…·Ondřej Mikula
This study reveals repeated introgressive hybridization and population expansions in African giant shrews, identifying genomic processes underlying incipient speciation.
Elizabeth D. Drake, Xavier Bal, Jill G. Pilkington…·Hannah Froy
The study examines whether resource competition accelerates senescence in Soay sheep, finding no evidence of sex-specific variation in age-related decline under increased population density.
May Wang, Mohammadebrahim Akhavizadegan, Jen-Yu Wang…·Kevin H.-C. Wei
The paper studies a young Y chromosome in Drosophila albomicans that recombines with the X chromosome before recombination shutdown, maintaining long-range linkage without inversions.
Sina Türeli, Theo M. Bestebroer, Sarah James…·Derek J. Smith
This paper introduces a high-throughput pipeline for selective mutational scanning in influenza viruses, enabling rapid assessment of variant fitness and escape potential.
Henrique Teotónio, Stephen Robert Proulx
This study shows that maternal traits evolve adaptively only when maternal environments provide reliable cues predicting offspring selection environments.
Felix L. Wu, Danielle E. Khost, Patrick McKenzie…·Robin Hopkins
The paper presents chromosome-level genome assemblies and population genetic data for three Phlox species, revealing extensive genetic variation and widespread gene flow during speciation.
Wei Yuan, Xuan Jing, Zi-Qiang Xu…·Jun‐Jie Gu
The paper introduces a character-partitioning framework to separate phylogenetic signal from ecological information in mosaic fossils, using mid-Cretaceous crickets as a case study.
Evgeny V. Esin, Ludmila S. Zinevich, Kirill Kuzishchin…·Г. Н. Маркевич
This study traces the evolutionary history of Kamchatkan charrs, showing that postglacial expansion from Lake Kronotskoe led to new populations with generalized morphology due to hybridization and environmental pressures.
Chloe Melo-Gavin, Karl Grieshop, Aneil F. Agrawal
The paper uses experimental evolution in Drosophila to separate male and female gene pools, finding diverged genes show elevated intersexual genetic correlation and enrichment for male-biased splicing-related SNPs.
Arnon Plianchaisuk, Spyros Lytras, Hiroyuki Hikida…·Kei Sato
This study analyzes poxvirus gene repertoires and finds that they evolve through expansion-biased birth-and-death dynamics and genome architectural constraints.
Jory van Thiel, Noah L. Dowell, Cara Francesca Smith…·Sean B. Carroll
This study traces the genomic origins of four procoagulant venom toxins in Australian snakes and identifies a fifth toxin, showing two distinct evolutionary paths for their development.
Rama Sarvani Krovi, Nermeen R. Amer, Alicja Wierzbicka…·Łukasz Kajtoch
The paper shows that genomic diversity metrics vary in their ability to detect phylogenetic and ecological patterns in saproxylic beetles, emphasizing the importance of denominator choice.
REDQuanTEA improves detection of adaptive traits by using replication and ABC to account for extrinsic variance, outperforming ANOVA in simulations.
Zhaoyan Zhong, Yufei Zhou, Hui Wang…·Jin Sun
This paper reconstructs the ancestral gastropod karyotype and shows lineage-specific chromosomal strategies associated with habitat transitions.
Gabriel A Reyes Castellon, Ghada Aimadeddine, Caleb R Chiao…·Richard P. Meisel
This study examines the effects of chromosomal inversion arrangements in Drosophila pseudoobscura on life history traits, finding support for the coadaptation hypothesis over pleiotropy.
Iordana Zirdeli, Elias Georgoulis, Yiannis Pyrris…·Alexandros A. Pittis
The paper examines how gene duplication shaped the evolution of the vertebrate olfactory combinatorial code by analyzing receptor-ligand interactions and ancestral sequences.