Yiannis Pyrris

Pre-neuronal origins of monoamine and acetylcholine synthesis and transport

This study identifies the evolutionary origins of neurotransmitter synthesis and transport in fungi, showing these functions predate neurons and are linked to lysosomal processes in opisthokonts.

Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code

The paper examines how gene duplication shaped the evolution of the vertebrate olfactory combinatorial code by analyzing receptor-ligand interactions and ancestral sequences.

Expansion, functional diversification and gene fusion events in the Ato protein family

This study investigates the role of Ato proteins in carboxylic acid utilization in Candida albicans, revealing functional diversity and regulatory interactions among Ato family members.

High-resolution structures of the UapA purine transporter reveal unprecedented aspects of the elevator-type transport mechanism.

The paper reports cryo-EM structures of UapA, revealing the role of water, lipids, and the N-tail in its transport mechanism and subcellular trafficking.

Transmembrane helices 5 and 12 control transport dynamics, substrate affinity and specificity in the elevator-type UapA transporter

The paper investigates the role of transmembrane segments 5 and 12 in the UapA transporter, showing how specific residues affect transport dynamics, substrate affinity, and specificity.

Uracil/H+ symport by the FurE transporter challenges the rocking-bundle mechanism of transport in APC transporters

This study reveals the transport mechanism of uracil/H+ by FurE, showing a step-wise, induced-fit process rather than the rocking-bundle mechanism.