Discover, rate, and discuss biology preprints.

This study shows that CENP-C must be expressed during meiotic prophase to ensure proper chromosome segregation, unlike CID which remains stable without prophase expression.

This study investigates the molecular consequences of PQBP1 deficiency in Renpenning syndrome by analyzing gene expression and protein interactions, identifying dysregulated genes and a novel UPF3B isoform.

The paper creates a mouse model of Weaver syndrome and shows that inhibiting KDM6A/6B can reverse excessive osteogenesis caused by an EZH2 mutation.

This paper demonstrates that synthetic CTNS mRNA therapy can restore cystinosin function and reduce cystine accumulation in kidney cells and zebrafish models of cystinosis.

DYNATE identifies rare-variant association regions by dynamically aggregating genomic regions and controlling false discovery rate, finding a new ALS-associated gene.

This paper describes methods to collect and extract DNA from unhatched bird eggs to study early embryo mortality and its genetic factors.

This study performs a GWAS on Belgian Blue beef cattle to identify coding variants associated with body size and muscular development, finding new genes and variants linked to growth in mammals.

This study examines epigenetic age acceleration and telomere attrition in severe COVID-19 patients with ARDS, finding higher epigenetic age acceleration in deceased patients compared to recovered ones.

This paper introduces a transfer learning framework with false negative control to improve polygenic risk prediction across heterogeneous datasets.

This paper presents a framework to identify fertility gene targets for mammalian pest control by evaluating gene function, expression, and knockout results, identifying 16 male and 12 female fertility genes conserved across invasive species.

This study identifies YBR238C as a regulator of cellular aging in yeast, showing it modulates mitochondrial function through HAP4 and RMD9, and links TORC1 activity to mitochondrial feedback loops affecting aging.

This paper develops a CRISPR-Cas9 genome-editing protocol for Steinernema entomopathogenic nematodes, enabling targeted mutagenesis and phenotypic analysis in two species.

This study demonstrates that genomic selection can effectively predict herbage yield in forage oats with high accuracy, offering advantages over traditional marker-assisted selection.

The paper expands mitochondrial genome sampling across Saccharomycotina yeasts by extracting sequences from nuclear genome datasets, revealing trends in size, GC content, and gene presence.

CREaTor models cis-regulatory patterns using attention mechanisms and RNA-seq/ChIP-seq data, outperforming existing methods in predicting cCRE-gene interactions across cell types.

This study identifies anti-defense proteins in phages that inhibit bacterial immune systems like Gabija, Thoeris, and Hachiman.

This study shows MKT1 alleles modulate stress responses by stabilizing Puf3-target mitochondrial genes, with PBP1 and PUF3 playing key roles in this regulation.

The paper analyzes whole genome data from Fulani individuals to explore their genetic origins, suggesting a possible link to ancient Saharan populations rather than recent Eurasian admixture.

The paper analyzes QTLs for floral morphology differences between Gilia yorkii and G. capitata, identifying colocalized QTL intervals on chromosomes 6 and 9.