Discover, rate, and discuss biology preprints.

This study shows that blocking CR2/CD21 on both B cells and follicular dendritic cells reduces GC activity and autoimmunity in lupus by synergistically inhibiting B cell responses and reshaping immunological memory.

This study shows AhR restricts anti-inflammatory and pro-fibrotic traits in monocyte-derived macrophages by repressing key genes and limiting IL-10 signaling.

The paper analyzes CDRH2 lineage-state transitions in HIV-1 vaccine recipients comparing homologous and heterologous boosting regimens, finding positional differences in germline-to-nongermline changes.

This study compares the immunomodulatory effects of QS-21 and QS-7 in THP-1 macrophages, showing QS-7 enhances QS-21's activation while modulating inflammatory pathways.

This study develops multivalent mRNA vaccines against tuberculosis using antigens identified in zebrafish, showing protection in mice, guinea pigs, and comparable efficacy to BCG.

This study uses AlphaScreen profiling of extracellular vesicle markers to identify disease-specific signatures in ME/CFS, fibromyalgia, and long COVID, revealing distinct patterns of platelet, immune, and vascular pathway dysregulation.

This study shows that L-selectin shedding regulates neutrophil mobilization after heart attack but does not affect heart damage or remodeling.

This study identifies that T cell receptors from CD8 regulatory T cells direct the development of natural intraepithelial lymphocytes, challenging the role of Helios as a lineage-determining factor.

This study identifies how MAFB and MAF work together to shape human anti-inflammatory macrophage identity through IL-10 autocrine signaling and distinct functional roles.

This study identifies ancestry-specific peripheral immune cell shifts in Alzheimer's disease across multi-ethnic cohorts using RNA-seq and deconvolution methods.

The paper identifies ciliated keratinocytes as a pro-inflammatory cell state in psoriasis and atopic dermatitis, showing their association with disease activity and response to treatment.

This study evaluates TACK compounds Pyr01 and Pyr02 for their ability to selectively eliminate HIV-1-infected macrophages, finding Pyr01 effectively targets infected cells while sparing uninfected ones.

This study uses scRNA-seq to identify transcriptional signatures in CD4+ T cells from beryllium-exposed patients, revealing upregulated immune response genes and downregulated metabolic pathways.

This study tracks T cell responses after COVID-19 vaccination, identifying epitope-specific TCRs and revealing clonal succession patterns due to repeated antigen exposure.

This study compares transcriptional programs of neutrophils in COVID-19 and active tuberculosis, identifying maturation-associated differences as the most consistent distinguishing factor.

This study examines how CD19 CAR T cell therapy affects gut microbiota and immune responses in autoimmune disease patients, finding changes in microbiota composition and antibody repertoires linked to relapse risk.

This study identifies Ksp37 as a rapidly secreted NK cell protein that binds FGF2, suggesting a role in modulating extracellular environment and tumor-related processes.

This study shows that sex hormones and sex chromosomes have opposing effects on Th17 cell-mediated autoimmunity in mice, with hormones reducing disease severity and chromosomes increasing it.

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.