Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- NeurosciencebioRxivPreprint
A VTA-pontine GABA pathway biases locomotor direction via local and distal inhibition
Cristian González‐Cabrera, Rukhshona Kayumova, Ezia Guatteo…·Matthias Prigge
This study identifies a midbrain pathway from VTA to pontine reticular nucleus that biases locomotor direction through local and distal inhibition.
DOI 10.64898/2026.02.17.706301 - NeuroscienceeNeuroPeer-reviewed
Neural mechanisms of postural sway-related beta-band oscillations: a cortico-basal ganglia-thalamic network model of intermittent control
Shota Tsugaya, Akihiro Nakamura, Taishin Nomura
This paper develops a computational model of the cortico-basal ganglia-thalamic network to explain beta-band oscillations during postural sway, showing they emerge from intermittent control mechanisms.
DOI 10.1523/eneuro.0283-26.2026 - NeurosciencebioRxivPreprint
Assessing specificity testing in Lesion Network Mapping
Martijn P. van den Heuvel, Ilan Libedinsky, Sebastian Quiroz…·Luca Cocchi
This paper evaluates specificity testing in Lesion Network Mapping to address concerns about the biological interpretation and disease-specificity of derived brain circuits.
- NeurosciencebioRxivPreprint
Reactivation during sleep segregates the neural representations of episodic memories
Sarvia Aquino Argueta, Andrew Lazarus, Fiona Yao…·Eitan Schechtman
The paper shows that reactivation during sleep reduces overlap between neural representations of contextually linked memories, promoting object and context specificity.
- NeuroscienceMedComm – Future MedicinePeer-reviewed
GABAergic TH2 Amacrine Cells Participate in Spontaneous Wave Activity in the Developing Retina
Wenqiu Wang, Heather E. Durfee, Yasmeen Hassan…·Dao-Qi Zhang
This study identifies TH2 amacrine cells as active participants in retinal wave circuits during development, showing they are excited by starburst amacrine cells and later driven by bipolar cells through cholinergic and glutamatergic waves.
- NeurosciencebioRxivPreprint
Prefrontal 5-GABA-A receptors: putative role in perceptual learning
Matthew C. D. Bailey, Emilie Preisler, Clara Velázquez-Sánchez…·Jeffrey W. Dalley
This study investigates the role of GABRA5 in visual perceptual learning in rats, finding that GABRA5 expression in specific prefrontal cortex interneurons influences learning speed and acuity.
DOI 10.64898/2026.03.25.714213 - NeurosciencebioRxivPreprint
Hyperglycemia Activates Retinal Photoreceptors to Induce Neuroglial Inflammation
JORGE L. NUNEZ, JACOB M. POLOWAY, Yanxin Chen…·Irina De la Huerta
This study shows hyperglycemia increases photoreceptor production of inflammatory factors, which activate Muller glial cells and promote neuroglial inflammation in diabetic retinopathy.
DOI 10.64898/2026.08.27.747567 - NeuroscienceÅbo Akademi University Research PortalPeer-reviewed
CEREBRAL GLUCOSE UTILISATION DURING MUSICAL EMOTIONS: A MULTIMODAL FUNCTIONAL PET/MRI STUDY.
Vesa Putkinen, Andreas Hahn, Jouni Tuisku…·Lauri Nummenmaa
This study uses PET/MRI to examine glucose metabolism and hemodynamic responses during pleasurable music listening, revealing complementary neural activity patterns in brain regions associated with reward and emotion.
- NeuroscienceNeuropsychopharmacologyPeer-reviewed
NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration
Evan Knep, Angelica Velosa, Dana Mueller…·Nicola M. Grissom
This study shows that NMDA receptor loss in the medial prefrontal cortex impairs value updating and reward history integration in mice, mimicking schizophrenia-like cognitive deficits.
1 citation - NeuroscienceThe EMBO JournalPeer-reviewed
Amyloidogenic proteolysis of APP regulates glutamatergic presynaptic function
Akshay Kapadia, Fabian Schuhmann, Ezgi Daşkın…·Anne‐Sophie Hafner
The paper shows that APP-CTFβ regulates glutamatergic synaptic transmission and that Aβ counteracts its hyperexcitability effects in Alzheimer's disease.
1 citationtop 5% - NeurosciencebioRxivPreprint
Meso2EM: a cross-scale CLEM workflow linking mesoscale functional imaging to targeted electron microscopy
Ikumi Oomoto, Motohide Murate, Jaerin Sohn…·Yoshiyuki Kubota
Meso2EM links mesoscale functional imaging to targeted electron microscopy by preserving neuron identity across scale changes using shared landmarks.
DOI 10.64898/2026.08.25.746890 - NeuroscienceJournal of NeurosciencePeer-reviewed
Habit learning shapes activity dynamics in the central nucleus of the amygdala
Kenneth A. Amaya, James Eric Carmichael, Jeffrey J. Stott…·Kyle S. Smith
This study investigates how CeA neurons encode behavioral features during habit formation in rats performing a maze task, finding increased cFos expression and specific outcome-related activity.
2 citations - NeuroscienceNeurobiology of DiseasePeer-reviewed
Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35
Erin T. Williams, Maxwell A. Frye, Xi Chen…·Darren J. Moore
This study identifies a selective effect of the D620N VPS35 mutation on the brain-specific protein interactome in mammalian cells and brain tissue.
- NeurosciencebioRxivPreprint
Neural spiketrains and population vectors entangle neural representations
Melvin Vaupel, Valdemar Kargård Olsen, Sigurd Gaukstad…·Benjamin Adric Dunn
The paper introduces methods to disentangle latent variables driving neural activity by identifying bidirectional local matrices in neural data, applied to reveal movement-driven structures in motor cortex.
DOI 10.64898/2026.08.27.744867 - NeurosciencebioRxivPreprint
Schizophrenia-like neurodevelopmental pathology reshapes experience-dependent brain network remodeling following adolescent alcohol exposure
Charles Houdant, Maedeh Khalilian, Zoe Fortineau…·Mickaël Naassïla
This study shows that schizophrenia-like neurodevelopmental pathology alters how adolescent alcohol exposure affects brain network connectivity in rats.
DOI 10.64898/2026.08.26.747060 - NeuroscienceCellPeer-reviewed
The organization of visual pathways in the Drosophila brain
Judith Hoeller, Arthur Zhao, Aljoscha Nern…·Michael B. Reiser
The paper uses a Drosophila connectome to analyze visual pathway organization, revealing multi-layered, functionally interpretable pathways that transform visual input into perceptual representations.
DOI 10.1016/j.cell.2026.08.014 - NeuroscienceeNeuroPeer-reviewed
Epidermal and ECM Damage Following Pinch Injury Restricts Dendrite Regeneration in Drosophila
Mia A Brantley, Avantika Pandiyan, Annie C Danh…·Katherine L. Thompson-Peer
This study shows that dendrite regeneration in Drosophila is restricted by damage to surrounding epidermal cells and ECM following pinch injury, unlike laser injury which does not cause such tissue damage.
DOI 10.1523/eneuro.0058-26.2026 - NeuroscienceHuman Brain MappingPeer-reviewed
Weakening of subcortical and strengthening of cortical visual pathways across early adolescence
Arshiya Sangchooli, Elise Rowe, Robert E. Smith…·Marta Isabel Garrido
The paper uses longitudinal dMRI data to show that subcortical visual pathways weaken while cortical pathways strengthen during early adolescence, with both linked to faster visual processing.
- NeuroscienceJournal of VisionPeer-reviewed
An empirical three-dimensional metric field for color space
Jan J. Koenderink, Andrea J. van Doorn, Doris I. Braun, Karl R. Gegenfurtner
The paper presents a three-dimensional empirical metric field for color discrimination in sRGB space, showing spatially smooth and consistent structures across observers.
2 citations