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This study identifies STK25 as a kinase that phosphorylates PRKAR1A, inhibiting PKA signaling and reducing myocardial contractility in response to beta adrenergic stimulation.

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

The paper investigates how temperature affects PVN pre-sympathetic neurones via TRP channels, finding that Trpv4 contributes to thermosensitivity and ACf changes with temperature.

The paper identifies trans-syncytial nanopores in the placental syncytiotrophoblast as pathways for paracellular diffusion, supported by 3D visualization and mathematical modeling.

The paper introduces a method and R-package 'torpor' to assign metabolic rate measurements to torpor or euthermy in heterothermic endotherms, improving respirometry analysis standardization.

This study examines blood chemistry changes in goats during a 100-year rain event linked to coccidiosis, suggesting potential clinical applications and climate change implications.

This study identifies PIMT as a suppressor of endothelial activation and vascular inflammation by methylating TRAF6, inhibiting its function and reducing ICAM-1 expression.

This study shows grandmaternal allergen exposure creates distinct epigenetic changes in offspring that influence airway responses to allergens later in life, increasing asthma risk.

This study shows that a startling cue increases maximal motoneuron output in humans by enhancing synaptic input from subcortical pathways.

The study shows that the central clock, via Syt10-expressing neurons, drives most circulatory metabolic rhythms and rescues glucose intolerance, highlighting its role in circadian communication.

This study examines how reactive oxygen species-induced protein carbonylation reduces wheat seed vigor during aging by correlating carbonyl protein content with seed vitality and structural changes.

This study examines how parasite load affects metabolic rates and escape responses in pumpkinseed sunfish, finding that non-visible parasites reduce metabolic performance and responsiveness.

This study shows that sowing date affects temperature and light conditions during rice growth, which in turn modifies cadmium content in brown rice by regulating Cd-related gene expression.

This study investigates how photothrombotic stroke disrupts neurovascular coupling and shows that acute recovery of this coupling predicts sensorimotor function recovery.

This study shows that inhibiting HDAC6 with tubastatin A improves dystrophin-deficient muscle by reducing fibrosis and restoring microtubules and NMJ through Smad2/3 acetylation and TGF-β signaling inhibition.

A high-throughput screening platform identified 105 compounds that enhance human sperm motility, including novel targets like GABA signaling and PDE10A inhibitors.

This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.

This study investigates the genetic regulation of myokine signaling in humans, finding that biologic sex and sex hormones, particularly estrogens, dominate its variation across tissues.

The paper investigates the relationship between visceral fat, adipose tissue dysfunction, and hepatic insulin resistance in NAFLD patients, finding visceral fat is a significant risk factor independent of BMI.

The paper proposes a model where reduced blood-to-brain glucose transport explains hyperglycemia in type 2 diabetes and resolves multiple anomalies not addressed by traditional insulin resistance models.