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This study shows that increased early-life temperature in great tits accelerates telomere shortening, potentially reducing survival, without affecting growth or fledging survival.

This study shows that early UVBR exposure in tadpoles leads to telomere shortening and poorer condition in juvenile frogs, with dose and irradiance having opposing effects.

This study shows that sleep deprivation in mice leads to food deprivation and weight loss, suggesting energy deficits may underlie sleep loss effects.

The study shows that a C-terminal fragment of PC1 suppresses cystic disease in a murine model by interacting with a mitochondrial enzyme, affecting metabolism and mitochondrial function.

The paper derives an analytical solution for root pressure and applies it to a 7-meter bamboo shoot's hydraulic architecture.

This study identifies a mechanism by which the hERG1a N-linker region enhances hERG1b potassium channel expression at the plasma membrane, potentially offering a therapeutic target for Long QT syndrome.

This study shows that oxytocin signaling actively regulates cold stress responses in poikilothermic vertebrates, contrary to the belief that their responses are passive.

This study identifies a novel population of PDGFRβ+ mesenchymal cells that undergo mesenchyme-to-epithelial transformation during endometrial repair, contributing to tissue regeneration.

This study shows that BACE1, but not BACE2, knockout improves metabolic outcomes in mice on a high-fat diet, suggesting BACE1 inhibition may enhance metabolic homeostasis.

This study compares the molecular effects of ketogenic diet (KD) and protein restriction (PR) in mice, finding distinct metabolic responses despite both causing weight loss.

This study uses in vivo temporal labeling to show age-dependent changes in mouse platelet function and mRNA conservation.

This study shows that deleting TSC22D4 in hepatocytes reduces liver damage in NASH by improving mitochondrial function and lipid metabolism.

This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.

The paper introduces a model of mitochondrial ATP generation in rat hepatocytes, predicting reduced electron transport chain states and reactive oxygen species production during ischemia-reperfusion.

This paper develops a mathematical model of mitochondrial ATP generation in kidney and liver tissues to predict their responses to various mitochondrial dysfunctions and explain differences in their robustness.

This study examines how ozone exposure affects sickness and depressive-like behaviors in mice, linking these effects to serum amyloid A and kynurenine levels.

This study models and analyzes sex-specific effects of SGLT2 inhibition on kidney function in diabetic patients with and without uninephrectomy.

This study examines how insulin affects endometrial transcript expression in a microfluidic model, identifying altered translation-related transcripts that may reduce endometrial implantation capacity.

This study shows that individualized NMES training induces myonuclear accretion in mouse skeletal muscle without causing damage or hypertrophy.

This study develops a machine learning model to predict cardiac resynchronization therapy (CRT) response by combining clinical data with model-driven biomarkers from personalized cardiac simulations.