Author

M. R. MacArthur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:machine learning (classical)· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. R. Mitchell· 5 shared S. J. Mitchell· 4 shared A. E. Kane· 2 shared D. A. Sinclair· 2 shared A. Longchamp· 1 shared A. M. Hosios· 1 shared A. Valvezan· 1 shared B. D. Manning· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersPhysiology

J. R. Mitchell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cystathionine gamma lyase overexpression enhances neovascularization through NAD-dependent mechanisms

K. Kiesworo, M. R. MacArthur, P. Kip, T. Agius, D. Macabrey, M. Lambelet, L. Hamard, C. K. Ozaki, J. R. Mitchell, S. Deglise, S. J. Mitchell, F. Allagnat, A. Longchamp

This study shows that overexpressing cystathionine gamma lyase (CGL) enhances neovascularization in ischemic muscle through NAD-dependent mechanisms by improving endothelial cell migration.

bioRxiv · Sep 6, 2022 · PreprintPhysiology

Short-term Ketogenic Diet Induces a Molecular Response that is Distinct from Dietary Protein Restriction

K. Kalafut, S. J. Mitchell, M. R. MacArthur, J. R. Mitchell

This study compares the molecular effects of ketogenic diet (KD) and protein restriction (PR) in mice, finding distinct metabolic responses despite both causing weight loss.

bioRxiv · Dec 19, 2021Physiology

Gut Microbiota predicts Healthy Late-life Aging in Male Mice

S. Ke, S. J. Mitchell, M. R. MacArthur, A. E. Kane, D. A. Sinclair, E. M. Venable, K. S. Chadaideh, R. N. Carmody, F. Grodstein, J. R. Mitchell, Y.-Y. Liu

This study shows that gut microbiota signatures from young mice can predict healthy aging in older mice under calorie restriction.

bioRxiv · Jun 22, 2021Microbiology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology

Age and life expectancy clocks based on machine learning analysis of mouse frailty

M. B. Schultz, A. E. Kane, S. J. Mitchell, M. R. MacArthur, E. Warner, J. R. Mitchell, S. E. Howlett, M. S. Bonkowski, D. A. Sinclair

This paper develops two machine learning clocks to predict chronological age and life expectancy in mice using Frailty Indices, showing their accuracy in predicting lifespan and intervention efficacy.

bioRxiv · Dec 20, 2019Physiology