Author

J. R. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Animal Behavior & Cognition· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:behavioral assay· 2 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2

Frequent Co-Authors

M. R. MacArthur· 5 shared S. J. Mitchell· 4 shared A. E. Kane· 2 shared D. A. Sinclair· 2 shared M. A. Laine· 2 shared R. M. Shansky· 2 shared A. B. Porter· 1 shared A. J. Li· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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5 shared papersPhysiology

M. R. MacArthur

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Investigating Cryopreserved PBMC Functionality in an Antigen-Induced Model of Sarcoidosis Granuloma Formation

S. G. Seman, S. Bicer, M. W. Julian, P. J. Kramer, J. R. Mitchell, E. D. Crouser, L. W. LOCKE

This study evaluates the functionality of cryopreserved PBMCs in a sarcoidosis granuloma model, finding similar granulomatous responses to fresh cells.

bioRxiv · Mar 23, 2024Immunology

Sounding the alarm: sex differences in rat ultrasonic vocalizations during Pavlovian fear conditioning and extinction

M. A. Laine, J. R. Mitchell, J. Rhyner, R. Clark, A. Kannan, J. Keith, M. Pikus, E. Bergeron, I. Ravaglia, E. Ulgenturk, A. Shinde, R. M. Shansky

This study examines sex differences in rat ultrasonic vocalizations during fear conditioning and extinction, finding males emit more alarm calls and show stronger correlations between alarm calls and freezing behavior.

bioRxiv · Sep 13, 2022Animal Behavior & Cognition

Cystathionine gamma lyase overexpression enhances neovascularization through NAD-dependent mechanisms

K. Kiesworo, M. R. MacArthur, P. Kip, T. Agius, D. Macabrey, M. Lambelet, L. Hamard, C. K. Ozaki, J. R. Mitchell, S. Deglise, S. J. Mitchell, F. Allagnat, A. Longchamp

This study shows that overexpressing cystathionine gamma lyase (CGL) enhances neovascularization in ischemic muscle through NAD-dependent mechanisms by improving endothelial cell migration.

bioRxiv · Sep 6, 2022 · PreprintPhysiology

Short-term Ketogenic Diet Induces a Molecular Response that is Distinct from Dietary Protein Restriction

K. Kalafut, S. J. Mitchell, M. R. MacArthur, J. R. Mitchell

This study compares the molecular effects of ketogenic diet (KD) and protein restriction (PR) in mice, finding distinct metabolic responses despite both causing weight loss.

bioRxiv · Dec 19, 2021Physiology

Darting across space and time: Parametric modulators of sex-biased conditioned fear responding

J. R. Mitchell, S. G. Trettel, A. J. Li, S. Wasielewski, K. A. Huckleberry, M. Fanikos, E. Golden, M. A. Laine, R. M. Shansky

The paper investigates how experimental parameters influence sex-biased conditioned fear responses in rats, finding that darting, an escape-like behavior, varies with sex, shock reactivity, and training conditions.

bioRxiv · Jun 30, 2021 · PreprintAnimal Behavior & Cognition

Gut Microbiota predicts Healthy Late-life Aging in Male Mice

S. Ke, S. J. Mitchell, M. R. MacArthur, A. E. Kane, D. A. Sinclair, E. M. Venable, K. S. Chadaideh, R. N. Carmody, F. Grodstein, J. R. Mitchell, Y.-Y. Liu

This study shows that gut microbiota signatures from young mice can predict healthy aging in older mice under calorie restriction.

bioRxiv · Jun 22, 2021Microbiology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology

Age and life expectancy clocks based on machine learning analysis of mouse frailty

M. B. Schultz, A. E. Kane, S. J. Mitchell, M. R. MacArthur, E. Warner, J. R. Mitchell, S. E. Howlett, M. S. Bonkowski, D. A. Sinclair

This paper develops two machine learning clocks to predict chronological age and life expectancy in mice using Frailty Indices, showing their accuracy in predicting lifespan and intervention efficacy.

bioRxiv · Dec 20, 2019Physiology

Sex differences in seizure at presentation in glioma population

S. Ranjbar, B. J. Anderies, K. W. Singleton, S. K. Johnston, C. R. Rickertsen, A. Sharma, A. B. Porter, M. M. Mrugala, L. S. Hu, J. R. Mitchell, J. B. Rubin, K. R. Swanson

This study examines the association between tumor location and seizure risk in male and female glioma patients.

bioRxiv · Aug 4, 2019 · PreprintCancer Biology