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This study shows PRKAG2 variants cause cardiac hypertrophy and electrical changes in zebrafish, independent of glycogen storage, through AMPKγ2-myosin interactions.

This study compares acellular and red cell-based subnormothermic machine perfusion in human kidneys, finding no significant differences in transcriptional profiles or injury biomarkers between the two methods.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

This study characterizes the reproductive hormone profiles of markhors using non-invasive fecal samples to determine breeding seasons and reproductive timelines in captive populations.

This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.

This study examines age- and sex-dependent changes in bone microarchitecture and material properties in F344 x BN F1 rats, finding distinct aging patterns between males and females.

This study shows that timing DHODH inhibition during dawn reduces obesity in male mice by improving mitochondrial function and metabolic rhythms.

This paper evaluates a wearable dual-modality device combining IPG and PPG, showing IPG's superior sensitivity to arterial recovery and dynamic changes during napping.

This study investigates the role of cardiomyocyte caveolae and cavin-1 in myocardial function, revealing sex-dependent effects on ventricular compliance and resilience through mechanisms involving NOS signaling and fibrosis.

This study identifies three distinct hemodynamic phenotypes in high-altitude dwellers and links them to subclinical organ damage.

This study shows that reducing peptide deformylase activity in Methylobacterium extorquens increases formaldehyde resistance, with pleiotropic effects and tradeoffs in heat shock resistance.

This study creates a single-cell atlas of murine ankle synovium across age, identifying age-related changes in fibroblasts and macrophages linked to fibrosis.

This study identifies white adipose tissue lipolysis and circulating fatty acids as key mediators of metabolic tolerance to infection, showing improved survival in sepsis with beta3-adrenergic agonists.

This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.

This study shows that the SUN1 H118Y variant impairs CUL3 neddylation, leading to insulin resistance, and that inhibiting neddylation can restore insulin signaling.

This study identifies tissue-specific lncRNA responses to endurance exercise in rats, revealing sex differences and potential therapeutic implications.

This study examines the effects of capture-handling-restraint on wild great tits, finding short-term stress responses but no impact on reproductive success.

This study shows that sweet and bitter taste sensitivity peaks during the active period in humans and rats, indicating circadian regulation of taste at the peripheral level.

This study examines how a high-fat, high-sucrose, and high-salt diet affects metabolic outcomes in mice, finding increased gonadal fat and glucose intolerance despite reduced inflammation.