Chronopharmacological targeting of mitochondrial dihydroorotate dehydrogenase prevents diet-induced obesity in male mice
Florian Atger, M Durand, Mikaël Croyal, Albane Chavanne, Enora Le Questel, Yolène Foucher, Charlène Besnard, Ivan Nemazanyy, Soazig Le Lay, Xavier Prieur, Claire Pecqueur, Daniel Mauvoisin, David Jacobi
This study shows that timing DHODH inhibition during dawn reduces obesity in male mice by improving mitochondrial function and metabolic rhythms.
bioRxiv · Apr 21, 2026 · PreprintPhysiology