Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) underlies daily mitochondrial lysine-malonylation and hepatic metabolism
Enora Le Questel, Charlène Besnard, Florian Atger, Yolène Foucher, Alwéna Tollec, Victoria Pakulska, Arsênio Rodrigues Oliveira, Chloé Cloteau, Mathilde Gourdel, Ivan Nemazanyy, Amélie Thouzeau, Cédric Le May, Mikaël Croyal, Yohann Couté, David Jacobi, , Daniel Mauvoisin
This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.
Cell Reports · Aug 1, 2026Peer-reviewedPhysiology