Mikaël Croyal

Contributions of the gut microbiota and intestinal gluconeogenesis to metabolic adaptations in a mouse model of anorexia nervosa.

This study investigates how food restriction in a mouse model of anorexia nervosa affects gut microbiota and intestinal gluconeogenesis, revealing their roles in maintaining glucose homeostasis.

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with 15N and 13C natural abundance

This study examines how breast cancer metabolism and response to dichloroacetate relate to natural abundance of 13C and 15N isotopes in mouse tumor models.

Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) underlies daily mitochondrial lysine-malonylation and hepatic metabolism

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility

This study shows that Seipin regulates tripartite ER-mitochondria-lipid droplet contact sites, which are critical for adipocyte lipid storage and metabolic flexibility.

Chronopharmacological targeting of mitochondrial dihydroorotate dehydrogenase prevents diet-induced obesity in male mice

This study shows that timing DHODH inhibition during dawn reduces obesity in male mice by improving mitochondrial function and metabolic rhythms.

Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity

This study shows that extracellular vesicles with surface-anchored adiponectin improve insulin sensitivity and reduce obesity-related metabolic issues in mice.

Comparative Transcriptomic Analysis of Obesity and Lipodystrophy Reveals Shared Mechanisms and Novel Targets in Adipose Tissue Dysfunction

This study identifies a shared molecular signature in adipose tissue dysfunction across obesity and lipodystrophy, revealing common metabolic pathways and genetic loci associated with type 2 diabetes.

Late INa activation of cardiac TTX-sensitive sodium channels by AaH-II induces an arrhythmogenic phenotype

This study shows that AaH-II selectively activates TTX-S Nav channels, inducing arrhythmias in cardiac tissue, and suggests targeting these channels as an antiarrhythmic strategy.

Advancing Liver Gene Therapy: Enhanced Transduction with GalNAc-Bioconjugated rAAV Capsids

This study enhances liver gene therapy by conjugating GalNAc to rAAV capsids, improving transduction efficiency in mice while reducing required dosages.

Varied mutual growth inhibition between commensal yeasts and strains

This study investigates the varied mutual growth inhibition between commensal yeasts and Escherichia coli strains, identifying species-specific inhibitory effects and potential antimicrobial compounds.

Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.

The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.

Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.