Discover, rate, and verify biology preprints.

Citrate-Based Hydrogels Promote Closure of Infected Diabetic Wounds

This study evaluates citrate-based hydrogels for promoting wound closure in infected diabetic wounds, finding that formulations with copper nanoparticles and cell adhesion peptides significantly improve healing.

EGF and EREG regulate early oncoprotein-mediated tissue transformation in intestinal organoids.

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

Quantifying Excitation-Inhibition Harmony and Its Breakdown during Epileptogenesis in a Spiking Neural Network of the Hippocampal CA1

This paper quantifies excitation-inhibition balance in a spiking neural network model of hippocampal CA1, showing how disruptions in this balance lead to epileptogenic state transitions.

PyTorch Frustratometer: An Ultra-fast, Parallelized Tool for Proteome-Scale Local Energetic Frustration Analysis

The paper introduces a PyTorch-based tool for fast proteome-scale local frustration analysis, achieving 70-13,000x speedup over the original FrustratometeR.

Extracting and Updating Compact Colored k-mer Indexes

This paper introduces efficient methods to update colored k-mer indexes without rebuilding them from scratch, enabling dynamic maintenance of large genomic collections.

Phenotypic variation in divergent mitochondrial haplotypes in migratory three-spined stickleback

The paper investigates phenotypic differences associated with mitochondrial haplotypes in three-spined stickleback, finding effects on male gonadosomatic index and potential citrate synthase activity.

Glycine-Proline driven flexibility and interface-dependent conservation of six-residue {Omega}-loops in protein complexes

The paper analyzes six-residue Omega-loops in protein complexes, showing their structural constraints, sequence conservation patterns, and functional significance through sequence design and mutation mapping.

Midbrain neurons regulate the production of courtship squeaks in female mice

The paper identifies midbrain PAG neurons that regulate courtship squeaks in female mice but not pain-elicited squeaks, suggesting distinct neural pathways for different vocalizations.

Palindrome Presence, Location, and Structural Context Are Predictive of RNA Self-Association

The paper identifies three classes of palindromic regions in RNA based on structural context and availability, and evaluates their self-interaction stability using simulations.

Cell cycling throttles epithelial--mesenchymal transition

This study shows that G1 phase cells exhibit stronger EMT gene expression and RNA velocity than cycling cells, suggesting cell cycle phase influences EMT and should not be regressed out.

A novel patient with inherited TNF deficiency and tuberculosis

The paper reports three patients with inherited TNF deficiency who developed tuberculosis, showing TNF's essential role in immunity against M. tuberculosis.

Two decades of EU pesticide substitution have not reduced impacts on stream invertebrates

This study shows that two decades of EU pesticide substitution have not reduced environmental harm to stream invertebrates, as toxic pressure and impairment remained stable over time.

MELD: Mutation Effect Learning through Differential embeddings

MELD predicts SNV functional effects by directly training on wild-type versus mutant differences, outperforming post-hoc in-silico mutagenesis methods with fewer parameters.

A Neurocompliant Ionic Conductive Hydrogel Orchestrates Glial and Vascular Remodeling to Mitigate Traumatic Brain Injury

This paper develops a conductive hydrogel that reduces glial and vascular damage in traumatic brain injury models.

Higher stomatal density and smaller stomatal size associate with higher grain yield in winter wheat

This study links higher stomatal density and smaller stomatal size in winter wheat flag leaves to increased grain yield under field conditions.

Genome-scale modelling and stable isotope tracing reveal dynamic metabolic reprogramming in a human cardiac hypertrophy model

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

Allele-agnostic KCNH1 suppression rescues gain-of-function developmental epileptic encephalopathy

This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.

Functional analysis enables reclassification of SCN1A missense variants of uncertain significance in epilepsy

This paper uses automated patch-clamp assays to reclassify SCN1A missense variants, changing classifications for 50% of tested variants.

Human medial frontal neurons represent integrated semantic content and sensory evidence to inform decision-making

The paper identifies how medial frontal cortex integrates semantic content and sensory evidence for decision-making using human neurosurgical data and a vision-language model.

RabbitCD-HIT: Distributed High-Sensitivity Greedy Incremental Clustering for Billion-Scale Protein Sequences in Hours

RabbitCD-HIT clusters billion-scale protein sequences efficiently, achieving faster performance than CD-HIT on large datasets.