A. M. Shah

NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathway.

This study shows NRF2 activation in the heart increases the pentose phosphate pathway, protects against cardiac stress by reducing DNA damage and improving function.

Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

Effects of active dry yeast on growth performance, rumen fermentation characteristics and slaughter performance in beef cattle

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

Development and validation of a cellular host response test as an early diagnostic for sepsis

This paper develops and validates the IntelliSep Index (ISI), a diagnostic tool for sepsis using white blood cell biophysical properties from a single blood draw, showing high accuracy in predicting disease severity.

Relationship between True Digestibility of dietary Phosphorus and Gastrointestinal Bacteria of Goats

This study examines the relationship between phosphorus digestibility and gut microbiota in goats, finding significant correlations between TDP and specific bacterial taxa in different gastrointestinal regions.

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

This study develops a human iPSC-CM model of DOX-induced cardiac dysfunction in B-cell lymphoma patients with high-dose DOX treatment, showing increased susceptibility to DOX toxicity and impaired mechanical function.

Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies

This study shows prelamin A accumulation drives inflammation in both inherited and acquired cardiomyopathies, suggesting potential treatment strategies targeting inflammation.