P. Janning

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

This study characterizes the auto-inhibited state of Mical1 and shows how Rab8 binding releases inhibition through structural and biochemical analysis.

Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.

Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

Specialized pathogenic cells release Tc toxins using a type 10 secretion system

The paper identifies a type 10 secretion system in Yersinia entomophaga that releases Tc toxins via controlled cell lysis, revealing a novel lytic mechanism for toxin export.

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

This study designs and evaluates nucleotide-based covalent inhibitors for KRasG13C, showing they block nucleotide exchange and oncogenic signaling.

Mer3 helicase protects early crossover intermediates from STR complex disassembly during meiosis

This study identifies a new Mer3 complex with Top3 and Rmi1 and shows Mer3 inhibits the STR complex's anti-recombination activity, promoting crossover formation during meiosis.

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

The paper develops and compares protocols to produce and use highly active CDK1:Cyclin-B and CDK1:Cyclin-B:CKS1 complexes for mitotic protein machinery studies.

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

This study identifies Mer2 as a keystone in meiotic DSB formation by linking it to chromatin and DSB factors through biochemical interactions.

14-3-3 protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2

This paper identifies Bmh1 as a mediator of Hst2 recruitment to phosphorylated H3 tails, facilitating mitotic chromosome compaction through deacetylase activity.