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The paper identifies a mitochondrial co-expression module in microglia linked to cognition using snRNA-seq data from the SEA-AD dataset and shows that filtering by %MT may remove cognitively relevant cells.

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

This study uses fMRI to analyze naturalistic movie viewing and identifies a distributed brain network involved in audiovisual speech processing beyond traditionally studied regions.

The paper identifies immune-cell-specific genetic associations and drug targets in prostate cancer using integrative analyses of single-cell and bulk data.

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

This study identifies stromal COL12A1 as a key component of the extracellular matrix niche that supports invasion in appendiceal mucinous neoplasms and pseudomyxoma peritonei.

This paper demonstrates the directed evolution of a multimodal plastic-degrading enzyme capable of breaking down both polyesters and polyurethane.

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This paper develops a collagen-based 3D microtissue model of ovarian cancer that preserves structural, molecular, and therapeutic heterogeneity across different histotypes.

This study shows that DegQ and SwrA have opposing effects on DegU-dependent phenotypes in Bacillus subtilis through distinct mechanisms.

This study shows DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells, reducing ATR inhibitor efficacy, and suggests combining ATR and DNA-PK inhibition could enhance treatment in such cancers.

The paper identifies transient isoform remodeling as a key mechanism in early MAPKi resistance in melanoma, showing it is distinct from gene expression changes and linked to splicing regulators and developmental pathways.

This study investigates how changes in task relevance during redundant motor tasks distinguish between adaptation and structure learning mechanisms in monkeys.

This paper simulates protein evolution using programmable fitness objectives derived from modern protein models, showing that combined objectives improve evolutionary realism and molecular plausibility.

This study identifies regulators that control ECA biosynthesis in E. coli, showing ECA's role in acid and reactive nitrogen species stress resistance.

This study compares the metabolic and neuroendocrine effects of sleeve gastrectomy (SG) and gastric plication (GP) in obese mice, finding distinct outcomes despite similar weight loss.

TransPepMS verifies peptides not in reference proteomes by resolving ambiguities in mass-spectrometry data to distinguish genuine non-canonical peptides from false positives.

This study identifies genetic determinants of Brevundimonas-mediated attenuation of plant pattern-triggered immunity, finding TonB1 as the key factor.

This study demonstrates growing macroscopic functional human tissues on 3D-printed peptide hydrogels, enabling centimeter-scale neural organoids and directional axonal communication.