Discover, rate, and discuss biology preprints.

This paper identifies a fossilized brain in the trilobite Yunnanocephalus yunnanensis, revealing a bilaterally organized cerebrum with domains typical of euarthropod brain organization.

The paper identifies a vagal-to-sympathetic reflex that regulates lung vascular leak, showing that activating specific vagal neurons increases fluid leakage and that silencing them reduces leak during allergen exposure.

This study shows that engineered NK cells with a CD4-based CAR delay HIV rebound and alter the reservoir's composition in humanized mice.

This study shows that multivalent SH3/PRM interactions between endophilin and lamellipodin regulate membrane curvature by suppressing tubulation through phase separation.

This paper shows that the timing of forces in a robotic tug-of-war determines the outcome, with lagging teams winning under certain conditions, and introduces a decentralized control rule for cooperative transport.

The paper tests antiseizure medications on planarians to assess their ability to reduce seizure-like activity caused by neurotoxic compounds.

This study uses PacBio HiFi sequencing to assemble complete Plasmodium falciparum genomes from natural infections, revealing full repertoires of immune-related genes.

The paper develops a framework to analyze long-term sequence dynamics from context-dependent mutation processes, applied to somatic hypermutation in antibodies, revealing mutational biases and their effects on sequence evolution.

This study designs a reoriented H5 hemagglutinin vaccine to induce stem-directed antibodies, providing cross-protective immunity against diverse influenza A viruses.

The paper identifies genomic features of domoic acid biosynthesis in Pseudo-nitzschia diatoms, revealing expanded toxigenic diversity and environmental expression patterns.

This study shows germ granules in C. elegans act as stress-responsive hubs that reorganize RNA granule networks to protect germ cell viability during heat stress.

The paper identifies two collateral-defined prefrontal-striatal subnetworks that differentially regulate initiation and approach vigor during appetitive goal pursuit.

This study identifies structural and energetic determinants of monobody 12D4 recognition of KRAS variants using simulations and redesign, revealing key interactions and mutations for improved selectivity.

This study uses homing pigeons with temperature sensors to map 3D air temperature patterns in Rome, showing vegetation reduces heat and stabilizes temperatures near green areas.

This study shows that A/H3N2 influenza virus evolves differently in independent human airway cultures, with limited parallelism and novel mutations, suggesting evolutionary paths are influenced by selective context rather than intrinsic constraints.

The paper shows that individual-level social associations and social information use in mixed-species flocks affect foraging success in winter, with benefits varying by species.

This study evaluates chemical and physical epithelial disruption methods to enhance anorectal Chlamydia infection modeling in mice and tests a vaccine's efficacy in this tract.

This paper develops a mathematical model showing that induced muscle wasting (IMW) supports wound healing and that inhibiting IMW can prevent cachexia and restore muscle mass with nutritional support.

This study investigates the role of the creatine phosphagen system in trophoblast development and shows that disrupting it impairs bioenergetics, proliferation, and survival.

This study designs a peptidomimetic inhibitor that blocks Vibrio cholerae adhesin FrhA, showing nanomolar binding affinity and reduced biofilm formation.