Shuaiqi Guo

This study designs a peptidomimetic inhibitor that blocks Vibrio cholerae adhesin FrhA, showing nanomolar binding affinity and reduced biofilm formation.

This study identifies and characterizes RTX adhesins in seven bacterial species using long-read sequencing and AlphaFold3 modeling, revealing 35 unique variants with diverse LBD arrangements.

The paper investigates ribosome clusters in neuronal RNA granules, finding they contain stalled ribosomes and unique 3D structures that avoid quality-control mechanisms.

This study uses cryo-ET and subtomogram averaging to determine the in situ architecture of the Tad pilus machine in Caulobacter crescentus, revealing its assembly intermediates and structural framework.

This paper develops a bacteria-mimetic bioadhesive using a Vibrio cholerae-derived peptide to achieve strong, non-covalent mucus adhesion and drug delivery.

The paper identifies a tripeptide antagonist that blocks Vibrio cholerae adhesin FrhA with higher affinity than a previous pentapeptide ligand.

This paper introduces a living material platform that traps engineered E. coli in hydrogels using adhesin-mediated anchoring, reducing bacterial leakage and enabling controlled release of antimicrobial proteins.