Marc-Antoine Guery

This study uses PacBio HiFi sequencing to assemble complete Plasmodium falciparum genomes from natural infections, revealing full repertoires of immune-related genes.

The paper tracks malaria parasite lineages using de novo mutations in Plasmodium falciparum genomes from community infections in The Gambia, identifying recent mutations and transmission patterns.

This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.