Antoine Claessens

This study uses PacBio HiFi sequencing to assemble complete Plasmodium falciparum genomes from natural infections, revealing full repertoires of immune-related genes.

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.

The paper identifies large deletion variants in the PIMMS43 gene of Plasmodium falciparum and shows their geographic frequency variation and potential vector-specific selection.

The paper compares transcript levels of invasion ligand genes in Malaysian and Gambian Plasmodium falciparum isolates, finding regional differences in eba175, eba181, and Rh2b expression.

The paper tracks malaria parasite lineages using de novo mutations in Plasmodium falciparum genomes from community infections in The Gambia, identifying recent mutations and transmission patterns.

The paper introduces a new spatial entropy measure, RCE, to analyze categorical co-occurrences in spatial data across various fields, identifying environment-dependent interactions.

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.

This study identifies taurine as a host metabolite that inhibits malaria parasite cytoadhesion in asymptomatic infections, suggesting its potential as a therapeutic target.

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

The paper introduces upsAI, a machine learning classifier that accurately predicts Plasmodium falciparum var gene upstream groups from partial sequences, achieving high accuracy compared to existing tools.

This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.