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This study maps mitochondrial gene expression across the liver lobule in mice and humans, revealing spatial and temporal heterogeneity in mitochondrial function and structure.

GL-0001 improves bone fragility in a mouse model of osteogenesis imperfecta by enhancing bone material properties and growth, unlike bisphosphonates which primarily affect bone mass.

This study shows that plantaricin JK from Lactiplantibacillus plantarum inhibits EHEC O104:H4 and modulates gut microbiota in vitro, with engineered strains enhancing efficacy.

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

SUMMIT improves heritability and genetic correlation estimation across diverse ancestries using LD scores and GWAS summary statistics, showing better accuracy in non-European populations.

This study compares morphofunctional characteristics of colonic organoids from Muc2-/- mice and wild-type mice, finding differences in size, structure, proliferation, and stem cell proportion.

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

The paper introduces a PCR-based assay that accurately distinguishes between Plasmodium ovalecurtisi and Plasmodium ovalewallikeri, with high sensitivity and specificity for malaria diagnosis.

The paper identifies ChEC108 as a fungal effector that targets plasmodesmata in Arabidopsis, binds HIPP6, and induces plasmodesmal closure to restrict fungal spread.

This paper shows that coupling species' demography and interactions changes the structural stability of ecological communities in non-linear ways.

The paper quantifies mating strategies in yeast gametes, revealing a reproductive hierarchy where sibling gametes have divergent mating trajectories and temporal heterogeneity shapes compatibility.

This study shows that multivesicular release dominates synaptic transmission in vivo, enhancing reliability and enabling non-binary signaling at single synapses.

This study shows that multicellular systems coordinate force generation and invasive migration through oscillatory mechanochemical feedback in 3D matrices.

The paper identifies common and sex-biased aging biomarkers in skeletal muscle transcriptomes across six species, revealing shared and divergent molecular mechanisms of aging.

The paper decomposes meerkat alarm-calling behaviour into threat discrimination and response escalation to study context-dependent predation risk perception.

This study shows dopaminergic medication improves force steadiness and reduces motor unit variability in Parkinson's disease during both steady and least steady contraction periods.

This study evaluates MR-guided focused ultrasound targeting the nucleus accumbens to reduce fentanyl motivation in rats, finding no significant effect despite confirming NAc as the target.

DREM is a deep learning model that improves the identification of plant immune receptors by learning from sequence data, outperforming existing methods and identifying novel resistance proteins.

The paper integrates gene expression and B cell receptor data to capture complementary B cell information, revealing substructure supported by both transcriptional and receptor features.

This study examines how cardiac phase and acute stress influence affective and spatial response biases in decision-making tasks.