Discover, rate, and discuss biology preprints.

The paper introduces a method to identify key players in rare conformational transitions of proteins by analyzing transition corridors and testing their impact through computational and mutational approaches.

This study identifies inactivating CSTF2 variants in males with intellectual disability and shows they disrupt intronic polyadenylation patterns, linking CSTF2 to neurodevelopmental disorders.

This study investigates the adaptive radiation of butterflyfishes on coral reefs, finding a recent radiation in the Late Miocene linked to ecological opportunities from coral reef turnover and coral diversification.

The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.

The paper evaluates a rapid Nanopore-based microbiome profiling workflow for women's health outreach at a music festival, demonstrating its feasibility for fieldable citizen science initiatives.

The paper characterizes microbial communities and metabolic potential in northern palsa and peat ecosystems, finding distinct microbial profiles and highlighting hydrogen and carbon monoxide metabolism as key energy sources.

The paper shows that adhesion assembly, F-actin accumulation, and force generation follow the same time evolution at adhesion sites, with F-actin retrograde flow being faster and not slowing over maturing adhesions.

This study identifies new GPR119 agonists and antagonists by screening a tera-scale chemical space using structure-based methods and validates them with cryo-EM structures.

This paper introduces a wireless headstage for simultaneous cortical, muscle, and movement recordings in freely moving mice, demonstrating its utility in seizure detection and behavior-related neural activity analysis.

This study identifies mQTLs for serum and urine metabolites across ancestries, revealing ancestry-specific genetic effects and linking them to disease traits.

The paper develops a spatial proteomics workflow to study early astrocytic remodeling in an ALS mouse model, finding that motor neurons are surrounded by GFAP-high environments earlier than previously observed.

This study shows that maternal separation alters cerebellar circuitry and synaptic plasticity, leading to behavioral and neurobiological deficits in mice.

This study determines the atomic structure of mycobacteriophage SWU1 using cryo-EM, revealing key architectural features critical for virion assembly and infection.

This study evaluates the effects of Lactobacillus postbiotic supplementation on intestinal permeability, nutrient digestibility, and gut microbiome/metabolome profiles in aging cats, finding no effect on permeability but improved nutrient digestibility and sequence-dependent microbiome changes.

This study shows that vitamin B3 supplementation protects mitochondria from antibiotic-induced damage, preserving bioenergetics and thermogenesis in Drosophila and human cells.

The paper uses in vivo single-cell CRISPR screens to study how tumor suppressor loss and genetic perturbations affect glioma states and immune recruitment in mice.

The paper investigates whether urban-rural differences in selection or pollen limitation explain a flower colour cline in Hesperis matronalis, finding no significant effects.

This paper introduces evidence-based re-identification to correct tracking mistakes in multi-animal behavior studies, showing improved reliability over time compared to existing methods.

This study shows that antigen-specific CD8+ T cells reduce atherosclerotic plaque burden and stabilize plaques by decreasing secondary necrosis and CD47 expression on foam cells.

This study investigates how ribosome-mediated protein folding imposes sequence constraints by analyzing mutations in E. coli DHFR using deep mutational scanning and fluorogenic sensors.