Discover, rate, and discuss biology preprints.

This study examines how breast cancer cell lines adapt to serum-free defined medium, revealing differences in proliferation, adhesion, and lipid metabolism across cell lines.

The paper identifies Early Progression Cells (EPCs) as stem-like cells in pancreatic cancer that drive progression and are associated with specific gene programs and interactions.

This paper introduces a method to model social behavior using decomposed linear dynamical systems, showing it captures complex, compositional actions more effectively than existing methods.

This study shows that Scn2a-deficient mice have altered serotonergic function and different behavioral responses to psilocybin compared to wild-type mice.

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

PPI-Caliper controls false discovery rate in protein interaction prediction using conformal calibration without retraining models.

This study identifies the chloroplast transporter RETICULATA as a regulator of palisade mesophyll cell division and expansion, influencing leaf air space patterning.

The paper uses Empirical Dynamic Modelling to show atmospheric pollution destabilized a small mammal community over 39 years in the Black Triangle of Europe.

The paper uses short and long-read sequencing to identify alternatively spliced and polyadenylated transcripts in mantle cell lymphoma, revealing novel splice variants and polyadenylation signals.

This study shows habitat degradation shifts metacommunities from stable to unstable regimes, increasing extinction risk, and highlights dispersal's role in stabilizing ecosystems.

The paper examines particle-associated prokaryotic communities in the Bering and Chukchi Seas, finding that lifestyle and water-mass origin, not depth, structure these communities.

This paper develops a multimodal prognostic model for pancreatic neuroendocrine tumors using clinicopathologic data and histology images, finding that stromal features are as prognostic as tumor cells.

The paper shows that combining ACE2dm-s1 with a STING agonist improves survival in GBM model mice, unlike losartan alone, and suggests ACE2dm-s1 modulates the tumor microenvironment.

This study investigates how larval competition affects gene drive performance in Aedes aegypti mosquitoes using agent-based models and Bayesian optimization.

This study identifies shared molecular signatures of inflammation and urothelial dysfunction across different IC/BPS phenotypes using multi-cohort transcriptomic analysis.

This study shows that stopping GLP-1RA treatment in mice with binge-like eating restores binge behavior and leads to weight gain beyond pre-treatment levels.

The paper develops a 31-marker spectral flow cytometry panel to simultaneously profile functional cytokines, AIMs, and FoxP3+ Tregs in human PBMCs under different conditions.

PLATE provides a global resource of food metaplasmidomes, offering curated catalogs and annotations for studying plasmid diversity and function in food ecosystems.

This study investigates plant-plant communication in tomato by analyzing metabolomic and volatile emissions changes in response to herbivory, showing mirror effects in immune system reprogramming between sender and receiver plants.

This study compares molecular features of SSc-NSIP and SSc-UIP with IPF, finding shared epithelial changes and distinct fibroblast programs.