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Sensory neurons gate a cortical plasticity window for immune encoding

The paper shows that sensory neurons open a multi-day cortical plasticity window aligned with immune responses, mediated by sequential activation of inhibitory and excitatory interneurons.

RELAY: Relational In-Context Learning for Cellular Perturbation Prediction

RELAY predicts cellular responses to perturbations by learning relational patterns from measured data, outperforming existing methods on unseen variable values and combinations.

Tandem repeats in methanogenic archaea and their viruses reveal a shared potential for rapid genomic diversification

The paper identifies tandem repeats in methanogenic archaea and their viruses, showing they contribute to genomic diversity and adaptation potential.

Sedimentary ancient DNA analysis from the Iron Age courtyard and cooking pit site of Rodskjaer in Troms, Northern Norway

This study uses sedimentary ancient DNA metabarcoding to analyze Iron Age courtyard and cooking pit sites, identifying plant and animal taxa and highlighting challenges from bioturbation and root penetration.

Whole methylome changes in Barrett's metaplasia, dysplasia, and cancer

The paper identifies methylation changes associated with dysplasia and cancer progression in Barrett's esophagus using whole-genome methylation profiles.

Why probe registration is crucial for infant fNIRS and HD-DOT? An evaluation across 49 newborns

This study evaluates probe registration accuracy in newborn fNIRS and HD-DOT, showing significant cap misalignment affecting spatial accuracy of functional images.

Genetic diversity and population structure of Ethiopian taro Colocasia esculenta (L.) Schott) as revealed by SSR markers

This study assesses genetic diversity and population structure of Ethiopian taro using SSR markers, finding low diversity at individual loci but high multilocus genotypic diversity and weak genetic differentiation among populations.

Quantum Dot-Based Non-invasive Monitoring of Sinusoidal Endothelial Scavenger Function in Steatohepatitis

This study develops a non-invasive method using quantum dots to assess liver sinusoidal endothelial cell scavenger function in MASH, showing reduced retention correlates with disease progression.

Oil biodegradation and marine oil snow formation in Arctic seawater microcosms at 4 °C

The paper investigates oil biodegradation and marine oil snow formation in Arctic seawater microcosms at 4°C, finding that Pseudomonas and Pseudoalteromonas dominate oil degradation, and UV weathering significantly affects PAHs.

Emergence and robustness of 3D complex tissue architectures from simple physical forces

This study builds a 3D mathematical model of adipose tissue showing complex architectures emerge from simple mechanical rules, suggesting mechanical forces drive tissue structure more than genetic programs.

Structure-Function Analysis of an Infantile Rhabdomyosarcoma Fusion-Oncogene Reveals Domain Requirements for Tumorigenesis

This study identifies the structural domains of the VGLL2::NCOA2 fusion-oncogene essential for tumorigenesis and suggests therapeutic targeting of these domains.

PSI photoinhibition and protection at low temperatures and in fluctuating light: An 30 ecophysiological vista

This paper reviews PSI photoinhibition in cucumber under chilling temperatures and fluctuating light, comparing causes, consequences, and protective mechanisms.

A Comparison and Validation of BIDS Apps for Preprocessing of UCB-J PET data

This study compares and validates two BIDS Apps, PETPrep and PICNIC, against in-house software for preprocessing UCB-J PET data, finding high consistency but region-dependent bias.

Bridging Bibliometrics and Biology: A Framework for the Relevance Scoring and Biological Stratification of Scalable MeSH Co-occurrence Networks

This paper introduces a framework to score and stratify MeSH co-occurrence networks for systematic literature reviews, improving the identification of relevant biological concepts.

An RNA-centric atlas of human cell cycle regulation

The paper defines an RNA-centric landscape of human cell cycle control by profiling various RNA features and identifies key RNA elements involved in cell cycle regulation.

Development and cross-cohort evaluation of a multimodal deep-learning model for ER, PR and HER2 status classification in breast cancer

This paper develops a multimodal deep-learning model for breast cancer biomarker classification and evaluates its performance across cohorts, finding high discrimination but limited incremental value over a simpler transcript-based model.

Resolving Gene-Metabolism Links through Multi-Metabolite mQTL Commonality Analysis

The paper develops a method to link genes to metabolism by analyzing commonality in metabolite features associated with mQTLs, demonstrating its effectiveness through three case studies.

Dissecting Genetic Variability and Multi-Trait Performance in Cucumber

This study evaluates 18 cucumber genotypes across two seasons for multiple traits to identify high-performing varieties with stable multi-trait performance.

Coupled Modeling of Tumor Volume and ctDNA Dynamics in HPV-Associated Anal Squamous Cell Carcinoma

The paper models tumor volume and ctDNA dynamics in HPV-associated anal cancer to predict immunotherapy response using patient-specific parameters.

A cytotoxicity dataset for data-driven design of ionizable lipid nanoparticles

The paper presents a curated dataset of 1,413 LNP cytotoxicity measurements to examine structure-activity relationships and develop computational models of lipid nanoparticle cytotoxicity.