A. A. Bridges

Pneumococcal Extracellular Vesicles Mediate Horizontal Gene Transfer via the Transformation Machinery

This paper shows pneumococcal extracellular vesicles carry DNA that can be transferred to competent cells via the transformation machinery, promoting horizontal gene transfer and potential antibiotic resistance spread.

Synergy between c-di-GMP and quorum-sensing signaling in Vibrio cholerae biofilm morphogenesis

This study shows that AI-2 and norspermidine synergistically enhance biofilm formation in V. cholerae by modulating c-di-GMP signaling and quorum sensing.

Quantitative input-output dynamics of a c-di-GMP signal-transduction cascade in Vibrio cholerae

The paper quantifies how c-di-GMP signaling via NspS-MbaA in Vibrio cholerae translates ligand binding into specific biofilm gene expression changes.

Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

This study identifies polyamine signals that regulate biofilm dispersal in Vibrio cholerae, showing that spermidine promotes dispersal while norspermidine inhibits it through MbaA and PotD1.

Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal

This study identifies signaling pathways, matrix-digestion enzymes, and motility factors controlling Vibrio cholerae biofilm dispersal through a high-content imaging screen.

Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

This study identifies Qtip as a phage-encoded antirepressor that disrupts prophage repressor function and localizes to bacterial poles, revealing distinct mechanisms of quorum-sensing activation.

The intra-genus and inter-species quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal

This paper investigates how two quorum-sensing autoinducers in V. cholerae, CAI-1 and AI-2, control biofilm formation and dispersal through distinct mechanisms.