Author

J. W. Rosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Organism:human· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Rudmann· 2 shared F. Rosconi· 2 shared H. Rowe· 2 shared M. Frank· 2 shared N. L. Hiller· 2 shared T. van Opijnen· 2 shared A. A. Bridges· 1 shared A. Arun· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

E. Rudmann

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Pneumococcal Extracellular Vesicles Mediate Horizontal Gene Transfer via the Transformation Machinery

S. Werner Lass, S. Camphire, B. E. Smith, R. A. Smith, J. A. Prentice, S. S. Yerneni, A. Arun, A. A. Bridges, J. W. Rosch, J. F. Conway, P. Campbell, N. L. Hiller

This paper shows pneumococcal extracellular vesicles carry DNA that can be transferred to competent cells via the transformation machinery, promoting horizontal gene transfer and potential antibiotic resistance spread.

bioRxiv · Dec 15, 2023 · PreprintMicrobiology

A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

F. Rosconi, E. Rudmann, J. Li, D. Surujon, J. Anthony, M. Frank, D. S. Jones, C. Rock, J. W. Rosch, C. D. Johnston, T. van Opijnen

The paper investigates how a bacterial pan-genome affects gene essentiality and shows that essential genes can evolve to become non-essential through genetic changes and mechanisms like functional redundancy and pathway rewiring.

bioRxiv · Feb 8, 2022Microbiology

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

D. Leshchiner, F. Rosconi, B. Sundaresh, E. Rudmann, L. M. Nieto Ramirez, A. T. Nishimoto, S. Wood, B. Jana, N. Bujan, K. Li, J. Gao, M. Frank, S. M. Reeve, R. E. Lee, C. O. Rock, , T. van Opijnen

This study creates a genome-wide atlas of antibiotic susceptibility targets in Streptococcus pneumoniae, identifying a 'tolerome' that influences resistance and highlights its evolutionary significance.

bioRxiv · Jan 26, 2022Microbiology

Magnetic Bead-Based Separation (MBS) of Pneumococcal Serotypes

A. York, E. T. Huynh, S. Mbodj, D. Yolda-Carr, M. Hislop, H. Echlin, J. W. Rosch, D. M. Weinberger, A. L. Wyllie

This paper develops a magnetic bead-based method to enrich pneumococcal serotypes from mixed samples, achieving enrichment from 0.1% to 10-90% in dual serotype mixtures.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Coinfection of Streptococcus pneumoniae reduces airborne transmission of influenza virus

K. Mueller Brown, V. Le Sage, A. J. French, J. E. Jones, G. H. Padovani, A. J. Avery, M. M. Myerburg, S. Schultz-Cherry, J. W. Rosch, N. L. Hiller, S. S. Lakdawala

This study shows that coinfection with Streptococcus pneumoniae reduces airborne transmission of influenza virus by decreasing viral shedding in the upper respiratory tract of ferrets.

bioRxiv · Nov 10, 2020Microbiology

A Tn-seq screen of Streptococcus pneumoniae uncovers DNA repair as the major pathway for desiccation tolerance and transmission

A. J. Matthews, H. Rowe, J. W. Rosch, A. Camilli

This study uses Tn-seq to identify DNA repair pathways critical for desiccation tolerance and transmission of Streptococcus pneumoniae.

bioRxiv · Nov 9, 2020Microbiology

Experimental Evolution in vivo to Identify Selective Pressures During Pneumococcal Colonization

V. S. Cooper, E. Honsa, H. Rowe, C. Deitrick, A. R. Iverson, J. J. Whittall, S. L. Neville, C. A. McDevitt, C. Kietzman, J. W. Rosch

This study uses experimental evolution in mice to identify genetic adaptations of Streptococcus pneumoniae during nasal colonization and reveals fitness trade-offs in different host niches.

bioRxiv · Jan 15, 2020Microbiology