J. E. Silpe

Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities

The paper shows that a phage-encoded quorum-sensing receptor is activated by its host's autoinducer and inhibited by non-cognate autoinducers and synthetic inhibitors, affecting phage-host dynamics in bacterial communities.

Small protein modules dictate prophage fates during polylysogeny

The paper identifies small protein modules in phages that independently control prophage induction without relying on DNA damage cues, revealing alternative pathways for lysis in polylysogeny.

The gut bacterial natural product colibactin triggers induction of latent viruses in diverse bacteria

This study shows colibactin induces prophage lytic development in bacteria, with resistance mechanisms observed across diverse taxa.

Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway

The paper investigates the DPO-VqmA quorum-sensing pathway in Vibrio cholerae, revealing DPO-dependent and -independent activities of VqmA and structural insights into ligand binding.

Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

This study identifies Qtip as a phage-encoded antirepressor that disrupts prophage repressor function and localizes to bacterial poles, revealing distinct mechanisms of quorum-sensing activation.

Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers

The paper shows that phage genomes encode LuxR-type receptors that bind to host-produced AHL autoinducers, enabling phages to detect bacterial population density.