B. L. Bassler

The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces

This study shows that the LuxO-OpaR quorum-sensing cascade influences the lysis-lysogeny decision of phage VP882 based on host cell density and environment.

Natural Silencing of Quorum-Sensing Activity Protects Vibrio parahaemolyticus from Lysis by an Autoinducer-Detecting Phage

This study shows that a QS-deficient strain of V. parahaemolyticus is more susceptible to phage lysis, suggesting that QS suppression protects the host from viral attack.

Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities

The paper shows that a phage-encoded quorum-sensing receptor is activated by its host's autoinducer and inhibited by non-cognate autoinducers and synthetic inhibitors, affecting phage-host dynamics in bacterial communities.

Small protein modules dictate prophage fates during polylysogeny

The paper identifies small protein modules in phages that independently control prophage induction without relying on DNA damage cues, revealing alternative pathways for lysis in polylysogeny.

Quorum-sensing- and type VI secretion-mediated spatio-temporal cell death drives genetic diversity in Vibrio cholerae

This study shows that T6SS-mediated cell death in V. cholerae colonies drives genetic diversity through quorum-sensing-controlled spatio-temporal phases of cell death.

Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

This paper shows that disrupting the PqsE-RhlR interaction reduces P. aeruginosa infection in mice and presents new molecules targeting the PqsE active site.

LuxT is a Global Regulator of Low-Cell Density Behaviors Including Type III Secretion, Siderophore Production, and Aerolysin Production in Vibrio harveyi

This paper identifies LuxT as a global regulator in Vibrio harveyi that controls over 400 genes involved in low-cell density behaviors, including type III secretion, siderophore production, and aerolysin toxin biosynthesis, through SwrZ-dependent and -independent mechanisms.

Quantitative input-output dynamics of a c-di-GMP signal-transduction cascade in Vibrio cholerae

The paper quantifies how c-di-GMP signaling via NspS-MbaA in Vibrio cholerae translates ligand binding into specific biofilm gene expression changes.

Mechanism underlying the DNA-binding preferences of the Vibrio cholerae and vibriophage VP882 VqmA quorum-sensing receptors

This paper investigates the mechanism by which VqmAPhage and VqmAVc, homologous quorum-sensing receptors, exhibit different promoter-binding specificities, revealing key residues that determine their transcriptional preferences.

LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA

This paper identifies LuxT as a repressor of qrr1 in Vibrionaceae, showing it controls specific quorum-sensing behaviors by regulating unique downstream gene expression patterns.

Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

This study identifies polyamine signals that regulate biofilm dispersal in Vibrio cholerae, showing that spermidine promotes dispersal while norspermidine inhibits it through MbaA and PotD1.

Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal

This study identifies signaling pathways, matrix-digestion enzymes, and motility factors controlling Vibrio cholerae biofilm dispersal through a high-content imaging screen.

The Vibrio cholerae quorum-sensing protein VqmA integrates cell density, environmental, and host-derived cues into the control of virulence

This study shows VqmA integrates environmental and host cues with quorum sensing to regulate V. cholerae virulence.

Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway

The paper investigates the DPO-VqmA quorum-sensing pathway in Vibrio cholerae, revealing DPO-dependent and -independent activities of VqmA and structural insights into ligand binding.

Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

This study identifies Qtip as a phage-encoded antirepressor that disrupts prophage repressor function and localizes to bacterial poles, revealing distinct mechanisms of quorum-sensing activation.

Photo sensing and quorum sensing are integrated to control bacterial collective behaviors.

This study shows that light sensing via BphP regulates the KinB-AlgB two-component system, which controls biofilm formation and virulence in Pseudomonas aeruginosa.

Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers

The paper shows that phage genomes encode LuxR-type receptors that bind to host-produced AHL autoinducers, enabling phages to detect bacterial population density.