Author

A. A. Gimelbrant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

I. Kramnik· 2 shared O. S. Rukhlenko· 2 shared S. M. Yabaji· 2 shared A. Vanvalkenburg· 1 shared B. Bhattacharya· 1 shared B. Kholodenko· 1 shared B. N. Kholodenko· 1 shared E. Wood· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

I. Kramnik

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

bioRxiv · Mar 5, 2024Immunology

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee, B. Bhattacharya, E. Wood, M. Kasaikina, B. Kholodenko, A. A. Gimelbrant, I. Kramnik

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

bioRxiv · Feb 9, 2023 · PreprintImmunology