Author

O. S. Rukhlenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. N. Kholodenko· 3 shared I. Kramnik· 3 shared S. M. Yabaji· 3 shared A. A. Gimelbrant· 2 shared B. Bhattacharya· 2 shared L. Kobzik· 2 shared S. Chatterjee· 2 shared V. Zhernovkov· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

B. N. Kholodenko

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Author profile →

4 papers

Recent·Most cited

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

bioRxiv · Mar 5, 2024Immunology

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

H. Deng, O. S. Rukhlenko, D. Joshi, X. Hu, P. Junk, A. Tuliakova, B. N. Kholodenko, M. A. Schwartz

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

bioRxiv · Oct 24, 2023 · PreprintCell Biology

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee, B. Bhattacharya, E. Wood, M. Kasaikina, B. Kholodenko, A. A. Gimelbrant, I. Kramnik

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

bioRxiv · Feb 9, 2023 · PreprintImmunology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology