Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik
This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.
bioRxiv · Mar 5, 2024Immunology