Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
D. J. Kenney, A. K. O'Connell, A. E. Tseng, J. Turcinovic, M. L. Sheahan, A. D. Nitido, P. Montanaro, H. P. Gertje, M. Ericsson, J. H. Connor, V. Vrbanac, N. A. Crossland, C. Harly, A. B. Balazs, F. Douam
This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.
bioRxiv · Mar 8, 2024Immunology
S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik
This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.
bioRxiv · Mar 5, 2024Immunology
T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin
This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.
bioRxiv · Oct 18, 2022Microbiology
D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed
This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.
bioRxiv · Oct 13, 2022 · PreprintMicrobiology
L. Miorin, C. E. Mire, S. Ranjbar, A. J. Hume, J. Huang, N. A. Crossland, K. M. White, M. Laporte, T. Kehrer, V. Haridas, E. Moreno, A. Nambu, S. Jangra, A. Cupic, M. Dejosez, , A. E. Goldfeld
The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.
bioRxiv · Feb 8, 2022 · PreprintImmunology
D. J. Kenney, A. K. O'Connell, J. Turcinovic, P. Montanaro, R. M. Hekman, T. Tamura, A. R. Berneshawi, T. R. Cafiero, S. Al Abdullatif, B. Blum, S. I. Goldstein, B. Heller, H. P. Gertje, E. Bullitt, A. J. Trachtenberg, , F. Douam
This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.
bioRxiv · Jul 17, 2021 · PreprintMicrobiology
R. Rosenbloom, I. Gavrish, K. Seidel, I. Kramnik, N. A. Crossland
This study shows that B6.Sst1S mice develop more severe pulmonary M. avium infection with increased type 2 macrophage activation and reduced T cell density compared to wild-type mice.
bioRxiv · Jun 23, 2021 · PreprintPathology
D.-Y. Chen, N. Khan, B. J. Close, R. K. Goel, B. Blum, A. H. Tavares, D. Kenney, H. L. Conway, J. K. Ewoldt, S. Kapell, V. C. Chitalia, N. A. Crossland, C. S. Chen, D. N. Kotton, S. C. Baker, , M. Saeed
This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.
bioRxiv · Oct 27, 2020 · PreprintMicrobiology