Author

S. M. Yabaji

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

I. Kramnik· 4 shared B. Bhattacharya· 3 shared L. Kobzik· 3 shared S. Chatterjee· 3 shared N. Crossland· 2 shared O. S. Rukhlenko· 2 shared A. A. Gimelbrant· 1 shared A. B. Beeler· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

I. Kramnik

Mutual co-authors in cluster

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 17, 2023

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung

S. M. Yabaji, S. Lata, A. E. Tseng…·I. Kramnik

This study identifies aberrant macrophage activation and maladaptive lung repair as key factors promoting tuberculosis progression in the lung using a novel mouse model.

DOI 10.1101/2023.10.17.562695

mousespatial transcriptomics

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 9, 2023

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee…·I. Kramnik

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

DOI 10.1101/2023.02.09.527908

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 14, 2020

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov…·I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

DOI 10.1101/2020.12.14.422743

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 31, 2020

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

S. Chatterjee, S. M. Yabaji, B. Bhattacharya…·I. Kramnik

This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.

DOI 10.1101/691808

humanbulk RNA-seq

𝕏 PostBluesky