W. R. Bishai

This study identifies aberrant macrophage activation and maladaptive lung repair as key factors promoting tuberculosis progression in the lung using a novel mouse model.

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

The paper identifies an allosteric site in a L,D-transpeptidase that binds the sugar moiety of PG substrates and a second β-lactam molecule, revealing cooperative binding with the catalytic site.

This study shows that depleting myeloid-derived suppressor cells (MDSCs) using a diphtheria toxin-based fusion protein reduces Mycobacterium tuberculosis burden in mice.

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

This study shows that BCG overexpressing a STING agonist provides better protection against tuberculosis in guinea pigs.