Author

A. A. Kuehl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Siegmund· 3 shared S. Kempa· 2 shared A. Egners· 1 shared A. Fragoulis· 1 shared A. Huck· 1 shared A. Petersen· 1 shared A. Thiel· 1 shared A. Wilhelm· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

B. Siegmund

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

E. G. Avery, L.-M. Haag, V. McParland, S. M. Kedziora, G. J. Zigra, D. S. Valdes, M. Kirchner, O. Popp, S. Geisberger, O. Nonn, T. V. Karlsen, G. N'Diaye, A. Yarritu, H. Bartolomaeus, T. U. Bartolomaeus, , D. N. Mueller

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

Cardiovascular Research · Jan 10, 2025Peer-reviewedMicrobiology

Osteopontin in colitis-associated carcinoma

S. Manna, M. Sehn, D. Cardoso da Silva, J. J. Wiese, C. Heldt, I. Plumbom, T. Conrad, C. C. Husemann, K. Kleo, L. Derezanin, V. Dony, S. K. Farahani, F. Weiss, A. A. Kuehl, S. Schallenberg, , M. Schumann

This study investigates the role of osteopontin (SPP1/OPN) in colitis-associated carcinoma (CAC) using a multi-omics approach, revealing its indirect immunosuppressive role in the tumor microenvironment.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells

C. Yerinde, J. Keye, S. Durlanik, I. Freise, F. Nowak, H.-J. Hsiao, M. Letizia, S. Schlickeiser, B. Obermayer, A. Huck, M. Friedrich, H. Wu, D. Kunkel, A. A. Kuehl, S. Bauer, , C. Weidinger

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

bioRxiv · Sep 18, 2022Immunology

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

C. Iwert, J. Stein, C. Appelt, K. Vogt, R. J. Rainer, K. Tummler, K. Muehle, K. Stanko, J. Schumann, D. Uebe, K. Juerchott, J. Lisec, K. Janek, C. Gille, K. Textoris-Taube, , B. Sawitzki

This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.

bioRxiv · Apr 20, 2021 · PreprintImmunology

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

N. Rohwer, S. Jumpertz, M. Erdem, A. Egners, K. T. Warzecha, A. Fragoulis, A. A. Kuehl, R. Kramann, S. Neuss, I. Rudolph, T. Endermann, C. Zasada, I. Apostolova, M. Gerling, S. Kempa, , T. Cramer

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.

bioRxiv · Feb 28, 2018Cancer Biology