R. Kramann

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

This study identifies an immunogenic CD8+ T cell epitope associated with severe SARS-CoV-2 infection and characterizes its pathological features.

Deep learning-based molecular morphometrics for kidney biopsies

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

Microvasculopathy, Luminal Calcification and Premature Aging in Fetuin-A Deficient Mice

This study shows fetuin-A deficiency leads to microvascular calcification and premature aging in mice, associated with thrombosis and fibrosis rather than osteochondrogenic differentiation.

A functional landscape of chronic kidney disease entities from public transcriptomic data

This paper integrates transcriptomic data from nine CKD entities to delineate their molecular differences and identify potential therapeutic targets.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.