Author

B. Siegmund

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. A. Kuehl· 3 shared B. Obermayer· 2 shared C. Weidinger· 2 shared R. Glauben· 2 shared T. Conrad· 2 shared TRR241 IBDome Consortium· 2 shared A. Addante· 1 shared A. Aterido· 1 shared

Activity by Year

2022-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

A. A. Kuehl

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

E. G. Avery, L.-M. Haag, V. McParland, S. M. Kedziora, G. J. Zigra, D. S. Valdes, M. Kirchner, O. Popp, S. Geisberger, O. Nonn, T. V. Karlsen, G. N'Diaye, A. Yarritu, H. Bartolomaeus, T. U. Bartolomaeus, , D. N. Mueller

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

Cardiovascular Research · Jan 10, 2025Peer-reviewedMicrobiology

Ileal mucus viscoelastic properties differ in Crohns disease

C. Kramer, H. Rulff, J. F. Ziegler, N. Alzain, A. Addante, A. Kuppe, S. Timm, P. Schrade, P. Bischoff, R. Glauben, J. Duerr, M. Ochs, M. A. Mall, M. Gradzielski, B. Siegmund

This study examines ileal mucus viscoelastic properties in Crohn's disease patients and controls, finding significant differences in viscoelasticity and mesh size.

Mucosal Immunology · Aug 1, 2024Peer-reviewedBiophysics

Osteopontin in colitis-associated carcinoma

S. Manna, M. Sehn, D. Cardoso da Silva, J. J. Wiese, C. Heldt, I. Plumbom, T. Conrad, C. C. Husemann, K. Kleo, L. Derezanin, V. Dony, S. K. Farahani, F. Weiss, A. A. Kuehl, S. Schallenberg, , M. Schumann

This study investigates the role of osteopontin (SPP1/OPN) in colitis-associated carcinoma (CAC) using a multi-omics approach, revealing its indirect immunosuppressive role in the tumor microenvironment.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Interpretable Inflammation Landscape of Circulating Immune cells

L. Jimenez-Gracia, D. Maspero, S. Aguilar-Fernandez, F. Craighero, M. Boulougouri, M. Ruiz, D. Marchese, G. Caratu, J. Linares-Blanco, M. Berasategi, R. O. Ramirez Flores, A. Sanzo-Machuca, A. M. Corraliza, H. A. Tran, R. Normand, , Na

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

bioRxiv · Nov 28, 2023Immunology

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

V. Horn, C. Cancino, L. Steinheuer, B. Obermayer, K. Fritz, A. L. Nguyen, C. Plattner, D. Boesel, M. Burns, A. R. Schulz, E. Mantzivi, D. Lissner, T. Conrad, M.-F. Mashreghi, E. Sonnenberg, , A. N. Hegazy

bioRxiv · Oct 1, 2023Immunology

HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells

C. Yerinde, J. Keye, S. Durlanik, I. Freise, F. Nowak, H.-J. Hsiao, M. Letizia, S. Schlickeiser, B. Obermayer, A. Huck, M. Friedrich, H. Wu, D. Kunkel, A. A. Kuehl, S. Bauer, , C. Weidinger

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

bioRxiv · Sep 18, 2022Immunology