B. Sawitzki

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs

This study compares CD28 and 4-1BB costimulatory domains in CAR-Tregs, finding CD28 better preserves function and survival under tonic signaling.

Sex-associated differences in cytomegalovirus prevention: Prophylactic strategy is associated with a strong kidney function impairment in female renal transplant patients

This study compares prophylactic and pre-emptive strategies for preventing CMV syndrome in renal transplant patients, finding that the prophylactic strategy impairs kidney function in females.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

A novel approach reveals that HLA class 1 single antigen bead-signatures provide a means of high-accuracy pre-transplant risk assessment of acute cellular rejection

This paper develops a novel method using HLA class 1 single antigen bead signatures to predict acute cellular rejection risk pre-transplant with high accuracy.

Progressive change in killer-like receptor and GPR56 expression defines cytokine production of human CD4+ T memory cells

The paper identifies new surface markers to classify human CD4+ memory T cells into cytokine-producing subsets, finding KLRB1+KLRG1+GPR56+ cells produce the most cytokines.