Author

D. J. Fazakerley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. S. Shun-Shion· 3 shared D. C. Gershlick· 3 shared C. Pereira· 2 shared D. M. Norris· 2 shared D. Stalder· 2 shared J. R. Krycer· 2 shared O. J. Conway· 2 shared A. Alvarez-Guaita· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

A. S. Shun-Shion

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5 papers

Recent·Most cited

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

H. J. M. Baird, A. S. Shun-Shion, E. Mendes De Oliveira, D. Stalder, J. Eden, J. E. Chambers, I. S. Farooqi, D. C. Gershlick, D. J. Fazakerley

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.

bioRxiv · Mar 1, 2024Cell Biology

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

J. Tan, S. Virtue, D. M. Norris, O. J. Conway, M. Yang, C. Gribben, F. Lutgu, J. R. Krycer, R. J. Mills, I. Kamzolas, C. Pereira, M. Dale, A. S. Shun-Shion, H. J. Baird, J. A. Horscroft, , D. J. Fazakerley

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

Loss of Mfn1 but not Mfn2 enhances adipogenesis

J. P. Mann, L. Tabara, A. Alvarez-Guaita, L. Dong, A. Haider, K. Lim, P. Tandon, J. E. Minchin, S. O'Rahilly, S. Patel, D. J. Fazakerley, J. Prudent, R. K. Semple, D. B. Savage

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

C. Pereira, D. Stalder, G. Anderson, A. S. Shun-Shion, J. Houghton, R. Antrobus, M. A. Chapman, D. J. Fazakerley, D. C. Gershlick

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

bioRxiv · May 26, 2022 · PreprintCell Biology

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

X. Duan, D. M. Norris, S. J. Humphrey, P. Yang, K. C. Cooke, W. P. Bultitude, B. L. Parker, O. J. Conway, J. G. Burchfield, J. R. Krycer, F. M. Brodsky, D. E. James, D. J. Fazakerley

This study identifies TRARG1 as a GSK3 substrate that regulates GLUT4 trafficking and insulin sensitivity through phosphorylation events.

bioRxiv · Dec 7, 2020Cell Biology