O. Avinoam

High throughput screening identifies broad-spectrum Coronavirus entry inhibitors

This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.

Cell-mediated cholesterol crystal processing and clearance observed by 3D cryo-imaging in human atherosclerotic plaques

The paper uses 3D cryo-imaging to show that cells clear cholesterol crystals in human atherosclerotic plaques through enzymatic esterification.

Structured RhoGEF recruitment drives myosin II organization on large exocytotic vesicles

The paper investigates how Rho1 and RhoGEF2 regulate actomyosin organization during exocytosis in Drosophila, revealing a biphasic mechanism for membrane crumpling.

Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis

The paper studies fusion pore dynamics in large secretory vesicles, identifying MIM and actomyosin's roles in regulating pore expansion and constriction during exocytosis.

Machine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion

The paper uses machine learning to track continuous state transitions in myoblast differentiation and fusion, revealing timing and regulatory roles of ERK1/2 and p38.

Extracellular vesicle fusion visualized by cryo-EM

This study visualizes EV membrane fusion using cryo-EM and shows EVs remain fusogenic after acidification and re-neutralization, unlike retroviruses.

Genetically engineered MRI-trackable extracellular vesicles as SARS-CoV-2 mimetics for mapping ACE2 binding in vivo

This paper develops MRI-trackable extracellular vesicles displaying SARS-CoV-2 RBD to map ACE2 binding in vivo and screen viral variants.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis

The paper uses superresolution microscopy to show clathrin coats partially assemble on flat membranes before bending, and introduces a model to explain this process.

In-situ fiducial markers for 3D correlative cryo- fluorescence and FIB-SEM imaging

This paper demonstrates the use of fluorescently labeled lipid droplets as in-situ fiducial markers for correlating cryo-fluorescence and FIB-SEM imaging.