P. Klenerman

MAIT cells protect against sterile lung injury

This study identifies MAIT cells as protective against sterile lung injury by promoting anti-fibrotic pathways through cDC1 accumulation.

Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming

This study uses LN FNA combined with single-cell RNA-sequencing and proteomics to characterize immune cell populations and soluble interactors in human lymph nodes.

Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

The paper investigates how gonadal androgens affect type I interferon production by pDCs and IgG titres to BNT162b2 in adolescents co-vaccinated with LAIV.

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

This study identifies MERTK+ macrophages and fibroblasts involved in resolving fibrosis in frozen shoulder using single-cell analysis and suggests therapeutic strategies to enhance their interaction.

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

The paper identifies SQSTM1/p62 as an MR1 interacting protein and shows its role in regulating MAIT cell activation through autophagy pathways.

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

Human MAIT cells show clonal diversity but transcriptional and functional homogeneity

The paper analyzes MAIT cell clonal diversity and functional responses using single-cell RNA-seq and fRNA-seq, finding high TCR diversity and tissue-specific functional patterns.

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

The paper uses spatial transcriptomics to identify immune circuits in severe COVID-19 lung tissue, finding IFNγ response signatures linked to alveolar damage.

The P5-ATPase ATP13A1 modulates MR1-mediated antigen presentation

This study identifies ATP13A1 as a key regulator of MR1 surface expression through CRISPR/Cas9 knockout experiments in human cell lines.

Innate triggering and antiviral effector functions of activin A

This study identifies activin A as a cytokine triggered alongside type I IFN during viral infection, with antiviral effects in both in vitro and in vivo models.

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

This study identifies and characterizes MAIT cells in cattle, showing their functional response to bacterial infections and their enrichment in mucosal tissues.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

Autophagy in T cells from aged donors is maintained by spermidine, and correlates with function and vaccine responses

This study shows that spermidine maintains autophagy in aged human T cells, improving vaccine responses by enhancing IFN-gamma secretion and T cell function.

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.

Human intestinal tissue-resident memory CD8+ T cells comprise transcriptionally and functionally distinct subsets

This study identifies transcriptionally and functionally distinct subsets of human intestinal TRM cells, with β2-integrin marking a unique CD8+ TRM population.

Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity

This study shows that MAIT cell activation is essential for the immunogenicity of adenovirus vector vaccines, as it drives HCV-specific CD8 T cell responses.

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

This study investigates how TCR and inflammatory signals shape human MAIT cell functions, revealing their roles in tissue repair and effector responses.

Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionality

The paper defines the transcriptome of activated MAIT cells in mice and humans and shows how it changes during infection phases, revealing a tissue repair phenotype.

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

This study evaluates HBV vaccination and PMTCT as tools for elimination in HIV-coinfected populations using a clinical cohort and dynamic model, showing potential for significant public health impact by 2030.

MAIT cells contribute to protection against lethal influenza infection in vivo

This study shows MAIT cells protect against lethal influenza infection by accumulating and being activated early, with their absence increasing mortality in mice.

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.

Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways

This study shows that diverse Streptococcus pneumoniae strains activate MAIT cells via MR1-dependent and cytokine-driven pathways, with conserved riboflavin operon genes across strains.