Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics.
S. Verzini, M. Shah, F.-X. Theillet, A. Belsom, J. Bieschke, E. E. Wanker, J. Rappsilber, A. Binolfi, P. Selenko
This study examines megadalton-sized dityrosine aggregates of α-synuclein, revealing their structural disorder and dynamics, and their role in inhibiting classical amyloid formation.
bioRxiv · Jul 26, 2020Biophysics