Author

E. E. Wanker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Ast· 1 shared A. Belsom· 1 shared A. Binolfi· 1 shared A. Boeddrich· 1 shared A. Buntru· 1 shared A. Heinz· 1 shared A. Hutchinson· 1 shared A. Prigione· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperBiochemistry

A. Ast

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular architecture of synaptic vesicles.

U. Kravcenko, M. Ruwolt, J. Kroll, A. Yushkevich, M. Zenkner, J. Ruta, R. Lotfy, E. E. Wanker, C. Rosenmund, F. Liu, M. Kudryashev

This study uses cryo-electron tomography to describe the molecular architecture and structural heterogeneity of individual synaptic vesicles in mouse brains and cultured neurons.

bioRxiv · Apr 11, 2024Biophysics

Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein

M. G. Alteen, J. C. Deme, C. P. Alvarez, P. Loppnau, A. Hutchinson, A. Seitova, R. Chandrasekaran, E. Silva Ramos, C. Secker, M. Alqazzaz, E. E. Wanker, S. M. Lea, C. H. Arrowsmith, R. J. Harding

This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.

bioRxiv · Nov 21, 2022Biochemistry

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay

A. Zink, J. Conrad, N. S. Telugu, S. Diecke, A. Heinz, E. E. Wanker, J. Priller, A. Prigione

The paper develops a high-throughput MNH assay to assess ethanol-induced toxicity in human dopaminergic neurons and identifies potential modulating drugs.

bioRxiv · Aug 12, 2020Cell Biology

Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics.

S. Verzini, M. Shah, F.-X. Theillet, A. Belsom, J. Bieschke, E. E. Wanker, J. Rappsilber, A. Binolfi, P. Selenko

This study examines megadalton-sized dityrosine aggregates of α-synuclein, revealing their structural disorder and dynamics, and their role in inhibiting classical amyloid formation.

bioRxiv · Jul 26, 2020Biophysics

Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching

A. S. Wagner, A. Z. Politi, A. Ast, K. Bravo-Rodriguez, K. Baum, A. Buntru, N. U. Strempel, L. Brusendorf, C. Haenig, A. Boeddrich, S. Plassmann, K. Klockmeier, J. M. Ramirez-Anguita, E. Sanchez-Garcia, J. Wolf, E. E. Wanker

This study investigates the self-assembly of mutant huntingtin exon-1 fragments into complex fibrillar structures, identifying two nucleation mechanisms and their role in fibril formation.

bioRxiv · Mar 15, 2018Biochemistry