Author

C. A. M. Seidel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

A. A. Hyman· 2 shared A. Barth· 2 shared C. Gebhardt· 2 shared D. C. Lamb· 2 shared G. Krainer· 2 shared J. Folz· 2 shared M. Kar· 2 shared R. V. Pappu· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

A. A. Hyman

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Author profile →

6 papers

Recent·Most cited

Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

P. N. Ng`ang`a, J. Folz, S. Kucher, D. Roderer, Y. Xu, O. Sitsel, A. Belyy, D. Prumbaum, R. Kuehnemuth, T. E. Assafa, M. Dong, C. A. M. Seidel, E. Bordignon, S. Raunser

This study investigates the multi-state kinetics of Tc toxin prepore-to-pore transition, identifying intermediate states and transition times under various conditions.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

M. Kar, L. T. Vogel, G. Chauhan, H. Ausserwoger, T. J. Welsh, A. R. Kamath, T. P. J. Knowles, A. A. Hyman, C. A. M. Seidel, R. V. Pappu

The paper shows that glutamate reveals distinct energy and length scales for phase separation and clustering of FET family proteins in sub-saturated solutions.

bioRxiv · Aug 11, 2023 · PreprintBiophysics

A Minimal Model of CD95 Signal Initiation Revealed by Advanced Super-resolution and Multiparametric Fluorescence Microscopy

N. Bartels, N. T. M. van der Voort, A. Greife, A. Bister, C. Wiek, C. A. M. Seidel, C. Monzel

The paper uses advanced microscopy techniques to study CD95 oligomerization dynamics and identifies a minimal model for signal initiation.

bioRxiv · Nov 29, 2022 · PreprintBiophysics

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

G. Agam, C. Gebhardt, M. Popara, R. Maechtel, J. Folz, B. Ambrose, N. Chamachi, S. Y. Chung, T. D. Craggs, M. de Boer, D. Grohmann, T. Ha, A. Hartmann, J. Hendrix, V. Hirschfeld, , T. Cordes

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

bioRxiv · Aug 3, 2022Biophysics

Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

M. Kar, F. Dar, T. J. Welsh, L. Vogel, R. Kuhnemuth, A. Majumdar, G. Krainer, T. M. Franzmann, S. Alberti, C. A. M. Seidel, T. Knowles, A. A. Hyman, R. V. Pappu

This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.

bioRxiv · Feb 3, 2022Biophysics

Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools

M. Götz, A. Barth, S. S.- R. Bohr, R. Börner, J. Chen, T. Cordes, D. A. Erie, C. Gebhardt, M. C. A. S. Hadzic, G. L. Hamilton, N. S. Hatzakis, T. Hugel, L. Kisley, D. C. Lamb, C. de Lannoy, , S. Schmid

This study benchmarks eleven tools for inferring kinetic rate constants from smFRET trajectories using simulated and experimental data with varying challenges.

bioRxiv · Nov 23, 2021Biophysics