Author

A. Briley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Garcia-Sastre· 1 shared A. Mangoli· 1 shared B. R. Rosenberg· 1 shared B. T. Whitfield· 1 shared C. Fraley· 1 shared C. J. Pirozzi· 1 shared C. Si· 1 shared D. M. Ashley· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Garcia-Sastre

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Author profile →

2 papers

Recent·Most cited

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

S. Hariharan, B. T. Whitfield, C. J. Pirozzi, M. S. Waitkus, M. C. Brown, M. L. Bowie, D. M. Irvin, K. Roso, R. Fuller, J. Hostettler, S. Dharmaiah, E. A. Gibson, A. Briley, A. Mangoli, C. Fraley, , D. M. Ashley

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

bioRxiv · Apr 20, 2023 · PreprintCancer Biology

The regulatory factor ELF1 triggers a critical wave of transcription in the antiviral response to type I interferon

L. L. Seifert, C. Si, S. Ballentine, D. Saha, M. de Vries, G. Wang, M. Sadic, A. Briley, U. Schaefer, H. Moulton, A. Garcia-Sastre, S. Tripathi, B. R. Rosenberg, M. Dittmann

This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.

bioRxiv · Feb 14, 2019Immunology