S. Hariharan

Chemically induced in vivo retinal neuron regeneration rescues vision in mice

This study identifies a small molecule cocktail that reprograms Muller glia into retinal neurons, restoring vision in mice with RGC injury.

Screening for variable drug responses using human iPSC cohorts

The paper develops a drug screening platform using hiPSC lines from different donors to predict variable drug responses and mechanisms, showing potential for improving drug safety across diverse genetic backgrounds.

Development and validation of a high throughput screening platform to enable target identification in skeletal muscle cells from Duchenne Muscular Dystrophy (DMD) patients

The paper develops and validates a high throughput screening platform using morphological profiling to predict DMD disease phenotype in patient-derived myotubes.

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

Improving drug discovery using image-based multiparametric analysis of epigenetic landscape.

This paper introduces MIEL, an image-based method for epigenetic drug screening, showing it can detect active compounds, classify functions, and predict novel drug effects with higher resolution than traditional methods.