D. M. Ashley

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma

The paper analyzes gene expression in glioblastomas to show endolysosomes in non-tumor cells and immunosuppressive macrophages contribute to a pro-tumorigenic microenvironment.

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population

This study uses deep transcriptomic analyses to identify a CD34+ neuroectoderm-like population in gangliogliomas, revealing its role as a precursor cell controlling tumor heterogeneity and immune interactions.

Repurposing clemastine to target glioblastoma cell stemness

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells

This study shows SMARCAL1 loss-of-function mutations enable ALT in telomerase-negative glioblastoma cells, promoting tumorigenesis and telomere maintenance.

Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

Intratumor Childhood Vaccine-Specific CD4+ T cell Recall Coordinates Antitumor CD8+ T cells and Eosinophils

This paper shows that childhood vaccines can enhance antitumor immunity by coordinating CD4+ T cells, CD8+ T cells, and eosinophils in mouse models and correlates these effects with human transcriptome data.

Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.