Author

M. C. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. M. Ashley· 3 shared D. D. Bigner· 2 shared G. Zhang· 2 shared K. Stevenson· 2 shared M. Gromeier· 2 shared Y. Yang· 2 shared A. Briley· 1 shared A. C. Mutter· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

D. M. Ashley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Protein Dynamics Govern the Oxyferrous State Lifetime of an Artificial Oxygen Transport Protein

L. Zhang, M. C. Brown, A. C. Mutter, K. N. Greenland, J. W. Cooley, R. L. Koder

This paper shows that reducing protein dynamics in an artificial oxygen transport protein increases the oxyferrous state lifetime by limiting water penetration into the core.

Biophysical Journal · Nov 1, 2023Peer-reviewedBiophysics

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

S. Hariharan, B. T. Whitfield, C. J. Pirozzi, M. S. Waitkus, M. C. Brown, M. L. Bowie, D. M. Irvin, K. Roso, R. Fuller, J. Hostettler, S. Dharmaiah, E. A. Gibson, A. Briley, A. Mangoli, C. Fraley, , D. M. Ashley

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

bioRxiv · Apr 20, 2023 · PreprintCancer Biology

Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

Y. Yang, M. C. Brown, G. Zhang, K. Stevenson, M. Mohme, R. Kornahrens, D. D. Bigner, D. M. Ashley, G. Y. Lopez, M. Gromeier

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

Intratumor Childhood Vaccine-Specific CD4+ T cell Recall Coordinates Antitumor CD8+ T cells and Eosinophils

M. C. Brown, Z. P. McKay, Y. Yang, G. M. Beasley, D. M. Ashley, D. D. Bigner, S. K. Nair, M. Gromeier

This paper shows that childhood vaccines can enhance antitumor immunity by coordinating CD4+ T cells, CD8+ T cells, and eosinophils in mouse models and correlates these effects with human transcriptome data.

bioRxiv · Mar 14, 2022Immunology