J. Krishnan

HIF1α controls adipose tissue growth through metabolic rechanneling

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.

Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension

This study identifies the immunoproteasome's role in processing and presenting isoLG-adducts, linking it to hypertension and inflammation.

Circadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish

This study investigates circadian-regulated gene expression in skeletal muscle of cavefish and surface fish to determine if muscle dysfunction is due to circadian disruption.

Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation

The paper develops liver-derived cell lines from cavefish Astyanax mexicanus to study metabolic adaptation and provides their characterization.

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

Decontamination of Common Healthcare Facility Surfaces Contaminated with SARS-CoV-2 using Peracetic Acid Dry Fogging

This study evaluates the effectiveness of peracetic acid dry fogging in decontaminating SARS-CoV-2 from various healthcare surfaces, finding it completely inactivates the virus after one hour.

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

Adaptation to low parasite abundance affects immune investment strategy and immunopathological responses of cavefish

This study shows that cavefish, adapted to low parasite abundance, have a more sensitive immune system with reduced proinflammatory responses and shifted immune investment to adaptive immunity.